吸入必可酮为主防治儿童哮喘的研究

为探讨必可酮(BDP)防治儿童哮喘的价值,我们以吸入BDP为主防治儿童哮喘118例,均随访2午以上,年龄5～14岁,平均病程5.1年.轻、中、重症分别为15.46和57例.BDP每日吸入300～400μg,连用1年以上,发作时辅以对症治疗,重症给全身激素3～5天。结果:近期总有效率96.61％,远期疗效为94.54％。治疗3个月后PEFR明显升高,停药1年后仍在正常范围.嗜酸粒细胞自治后5个月起明显降低,血清皮质醇(F)治前显著降低,治后1年略升高,停药1年后明显升高。表明该法治疗哮喘效果满意且稳定,对肾上腺皮质功能无明显影响。

Researching In Effect of Preventing And Treating Children Asthma Mainly By Inhaled BDP

To probe the value of preventing and treating of children asthma with becolomethasone dipropi-onte(BDP) ,we prevented and treated 118 asthmatic children and took follow -up for more than two years,age 5 -14 years,mean disease course 5. lyears. Mild,moderate and severe patients were 15,16 and 57 cases respectively. Inhaled BDP was given in 300-400μg daily for more than a year continously. Acute stage patients aided by symptomic treatment, severe asthma were given in general storods for 3-5 days. Result short-term effective rate was 96. 61 % ,and Long-term effective rate was 94. 54%. After treatment for three years,PEFR evidently rised and was within normal range after a year without the medication. Since five monthes after treatment,number of EOS decreased evidently,and serum cortisol significantly declined,by comparition with that before treatment, slightly increased after a year and increased significantly after a year without the medication. This suggests that effecacy of the method is satisfing and stable, moreover, there is no significant effect on adrenal function.