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活血化瘀方对大鼠肝星形细胞活化的影响
引用本文:江涛,郭顺根,蒙一纯. 活血化瘀方对大鼠肝星形细胞活化的影响[J]. 北京中医药大学学报, 2001, 24(3): 43-45
作者姓名:江涛  郭顺根  蒙一纯
作者单位:北京中医药大学组织学与胚胎学教研室
摘    要:活血化瘀方有较好的抗肝纤维化作用 ,为探讨活血化瘀方影响肝纤维化发生、发展的作用机制 ,我们采用MTT法检测活血化瘀方药物血清对HSC增殖的影响 ,免疫细胞化学法研究活血化瘀方药理血清对HSC表达α SMA的影响。结果表明 ,药物血清组MTT法OD值、α SMA阳性染色吸光度分别为对照组的 58 8%、51 2 % (P <0 0 1)。活血化瘀方药物血清与γ IFN有相似作用 ,能够通过抑制HSC增殖、α SMA的表达抑制体外培养的HSC的激活。

关 键 词:中药  肝纤维化  肝星形细胞  增殖  α平滑肌肌动蛋白
修稿时间:2001-01-16

Effects of Huoxuehuayu Recipe on the Activation of Rat Hepatic Stellate Cells
Jiang Tao,Guo Shungen,Meng Yichun. Effects of Huoxuehuayu Recipe on the Activation of Rat Hepatic Stellate Cells[J]. Journal of Beijing University of Traditional Chinese Medicine, 2001, 24(3): 43-45
Authors:Jiang Tao  Guo Shungen  Meng Yichun
Abstract:In order to investigate the mechanism of the effects of Huoxuehuayu Recipe (HR) on the occurrence and development of hepatic fibrosis, the effects of rat HR-serum on the proliferation of hepatic stellate cells were detected by the MTT method, and the effects of rat HR-serum on α-SMA expression of hepatic stellate cells were detected by immunocytochemical assay. The results showed that the OD and α-SMA positive staining absorbance detected in the rat HR-serum group were 58.8% and 51.2% of those values detected in the control group respectively (P<0.01). The results suggest that the effects of rat HR-serum are similar to those of γ-IFN, which inhibit the activation of hepatic stellate cells cultured in vitro by inhibiting the proliferation of hepatic stellate cells and α-SMA expression.
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