土贝母皂甙微囊的特性及其用于肾动脉栓塞的实验研究

目的：研究中药土贝母皂甙囊作为血管栓塞剂的有效性、安全性及相关特性。方法：以中药土贝母皂甙为囊心，乙基纤维素为囊材制成微囊。用30只新西兰兔行肾动脉栓塞实验。结果：土贝母皂甙微囊为白色光滑的圆球形微粒，直径40～180μm，载药量为36％（W／W）；在40％泛影葡胺溶液中县浮分散性最好，经3F导管注射无堵管现象；在34℃生理盐水中约20d左右微囊全部破裂；栓塞后30d栓侧肾重量和体积均比对侧明显小（tw=102．1，tv=38．0，P＜0．001），主要栓塞在直径110～350μm叶间和弓形动脉，术后20d未见肾动脉再通及侧支循环形成。结论：土贝母微囊具有良好的血管栓塞作用和缓解特性，使用方便、安全，是一种较理想的末梢型血管栓塞剂。

Characteristics of ethylcellulose microcapsules containing tubeimoside and its usage in the experimental study of renal arterial chemoembolization

Objective　To study the efficacy, safety and related characteristics of ethylcellulose microcapsules containing tubeimoside as a vascular embolization agent. Methods　The ethylcellulose microcapsules containing tubeimoside was prepared using tubeimoside from bolbostemma paniculatum of Chinese medicinal herb as the core, and ethylcellulose as the shell. Transcatheter renal arterial embolization was performed with the microcapsules in 30 New Zealand white rabbits. Results　The microcapsules were white, spherical, and smooth particles, with its size to range from 40-180 μm, and its drug content was 36%(W/W); It was divergened best in 40% meglucamine diatrizoate and suspended stably, easily injected through 3 F catheter without occlusion. All of the microcapsules ruptured in about 20 days when immersed in physiological saline at 37℃. The embolized kidneys were smaller than the normal kidneys in weight and volume after 30 days（tw=102.1, tv=38.0, P<0.001）. Serial slices of the kidneys showed that the microcapsules remained mainly at the interlobular artery and the arterial arch, which measured from 110 μm to 350 μm in diameter. The vessels maintained occlusive after 30 days without formation of collateral circulation. Conclusion　Ethylcellulose microcapsules containing tubeimoside were safe and effective with angioembolic function and slow-release. It was a potential peripheral artery embolization agent.