脑白质疏松症患者载脂蛋白E基因多态性与血脂水平的关系

目的　探讨脑白质疏松症患者载脂蛋白 E基因多态性与血脂水平的关系。方法　采用聚合酶链反应—限制片段长度多态性对 50例脑白质疏松症患者和 1 0 8例正常对照者载脂蛋白 E基因型进行分析并进行血脂水平测定。结果　脑白质疏松症患者 Apo E2等位基因频率为 0 .1 5,明显高于对照组的 0 .0 74(P<0 .0 5) ;含 Apo E2等位基因患者的甘油三酯、低密度脂蛋白 ;载脂蛋白 B的含量均高于 Apo E3等位基因患者。结论　载脂蛋白 E2等位基因可能是脑白质疏松症的一种遗传易感因子 ,Apo E基因多态性可能通过影响血脂水平而影响脑白质疏松症的发生。

The Relationship between Apolipoprotein E Gene Polymorphisms and Level of Serum Lipids in Patients with Leukoaraiosis

Objective To study the relationship between polymorphisms of apolipoprotein E gene and serum lipids in leukoaraiosis patients.Methods The polymerase chain reaction (PCR) and restriction fragment length polymorphism(RFLP)technique were used to detect ApoE genotype in 50 leukoaraiosis patients and 108 control group and serum lipids levels were detected also.Result The frequency of ApoE2 allele in the leukoaraiosis group was significantly higher than that in the control group(P<0.05).The levels of TG?LDL c and ApoB in leukoaraiosis with ApoE2 group were significantly higher than those with the ApoE3 group.Conclusion Allele ApoE2 seemed to be a genetic susceptible factor for leukoaraiosis.ApoE gene polymorphism might be related to leukoaraiosis by affecting serum lipids levels.