人乳腺球蛋白及Ki-67在乳腺癌中的表达及临床意义

目的探讨人乳腺球蛋白及Ki-67在乳腺癌组织中的表达及临床意义。方法随机选取152例乳腺癌病人作为实验组,并选取30例乳腺良性病变(纤维腺瘤)作为对照组,应用免疫组化Maxvision法检测人乳腺球蛋白及Ki-67在乳腺癌组织及乳腺良性病变组织中的表达,并比较其表达差异性和相关性。结果人乳腺球蛋白在乳腺癌组及乳腺良性病变组织中的表达率分别为51.3%、0.00%,人乳腺球蛋白在乳腺癌组和乳腺良性病变组表达差异有统计学意义(P<0.05)。人乳腺球蛋白的阳性表达与淋巴结转移、组织学分级、临床分期、c-erbB2(人表皮生长因子受体)有关(P<0.05),与年龄、月经情况、诊断时肿瘤大小无关(P>0.05)。Ki-67在乳腺癌组及乳腺良性病变组织中的表达率分别为68.7%、0.00%,Ki-67在乳腺癌组织和乳腺良性病变组表达差异有统计学意义(P<0.05)。Ki-67的阳性表达与临床分期、肿瘤大小、淋巴结转移情况有显著相关性(P<0.05),与患者的年龄、月经状况无关(P>0.05)。结论人乳腺球蛋白及Ki-67可能参与了乳腺癌的发生发展过程,对乳腺癌的浸润和转移及预后评估具有一定的临床参考意义。

Expression and Clinical Significance of Human Mammaglobin and Ki-67 in Breast Cancer

Objective To study the expression and significance of human mammaglobin and Ki-67 in breast cancer. Methods The expressions of human mammglobin and Ki-67 detected by immunohistochemistry in 152 cases of breast cancer and 20 cases of benign breast diseases and its correlations to clinicopathlologic features were analyzed. Results The positive expression rate of human mammagloin in 152 cases of breast cancer were 51.3%(78/152),which was improved compared with the expressions in benign breast diseases that was 0.00%(0/30).The positive expression of human mammaglobin had notabe correlativity with axillary lymph node metastasis,clinical oeriodization,histologic classification and epidermal growth factor receptor people,but the relation with age,menstrual condition,tumor size.The positive expression rate of Ki-67 in 152 cases of breast cancer was 68.7%(104/152),which was improved compared with the expressions in benign breast diseases that was 0.00%(0/30).The positive expression of Ki-67 had notabe correlativity with axillary lymph node metastasis,clinical oeriodization,histologic classification and epidermal growth factor receptor people,but the relation with age,menstrual condition,tumor size. Conclusion Human mammaglobin and Ki-67 may participate in proceeding of breast cancer.It has certain coinical significance on evaluating invasiveness and metastasis in breast cancer.