血清降钙素原检测在慢性阻塞性肺疾病急性加重期的临床意义

目的 本文旨在探讨血清降钙素原(Procalcitonin,PCT)对慢性阻塞性肺疾病急性加重期(AECOPD)患者抗生素应用的指导意义.方法 将60例慢性阻塞性肺疾病急性加重期患者随机分为PCT指导组和对照组,PCT指导组当PCT＜0.15 μg/L时停用或不使用抗生素,对照组根据实验室检测结果、临床经验决定抗生素的使用,观察两组患者抗菌药物使用时间、费用及住院天数.结果 血清降钙素原组患者的抗生素使用天数(P=0.005)、抗生素使用率(P=0.023)、抗生素费用(P=0.001)、总费用(P=0.006)明显小于对照组,两组具有统计学差异(P＜0.05).结论 PCT可以用来指导AECOPD患者抗生素的使用与停用时机,能够有效减少患者使用抗生素时间及费用,同时减少患者住院时间.

Clinical Significance of Serum Procalcition in Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary

Objective This article aims to explore serum calcitonin original for chronic obstructive pulmonary disease(AECOPD) in patients with acute aggravating period antibiotic application significance. Methods 60 cases of acute exacerbation of chronic obstructive pulmonary disease were randomly divided into the PCT steering group and the control group,PCT steering group when PCT<0.15 μg/L deactivated with or without use antibiotics,the conventional therapy group according to the result of laboratory,clinical experience decided to the use of antimicrobials,observe two groups of the use of antibacterial drugs in time,cost and length of hospital stay. Results The serum procalcitonin group antibiotic use days(P=0.005),antibiotic use(P=0.023),antibiotic costs(P=0.001),total costs(P=0.006) was significantly less than the control group,the two groups had significant difference(P<0.05). Conclusion PCT can be used to guide the AECOPD patients of antibiotics use and disable timing,and patients can effectively reduce the use of antibiotics in time and costs,while reducing hospitalization time.