病毒性心肌炎患儿血清一氧化氮与微量元素锌的变化及临床意义

目的:探讨一氧化氮(NO)和微量元素锌(Zn)在病毒性心肌炎(VMC)中的作用及临床意义。方法:采用比色法、原子吸收分光光度分析法测定42例VMC患儿及23例正常健康儿的血清NO、Zn水平。结果:急性期VMC患儿血清NO含量为(61.35±18.92)μmol/L,较对照组(23.81±5.37)μmol/L、恢复期(33.95±8.86)μmol/L患儿明显升高(P<0.01);而急性期VMC患儿血清Zn浓度为(76.81±11.05)μmol/L,较对照组(116.28±11.76)μmol/L、恢复期(89.75±9.90)μmol/L患儿降低(P<0.01);VMC患儿急性期NO与Zn呈高度负相关(P<0.05)。结论:血清NO、Zn含量变化与VMC的发生发展有关。

Changes and clinical significances of nitric oxide and zinc in serum of children with viral myocarditis

Objective:To explore the effects and clinical significances of nitric oxide and zinc in children with viral myocarditis.Methods:Colorimetry and atomic absorption spectrophotometry were used to detect the serum levels of nitric oxide and zinc in 42 children with viral myocarditis and 23 normal healthy children.Results:The serum level of nitric oxide in viral myocarditis group during acute phase was(61.35±18.92) μmol/L,which was significantly higher than those in control group [(23.81±5.37) μmol/L] and viral myocarditis group during recovery phase [(33.95±8.86) μmol/L](P<0.01).The serum level of zinc in viral myocarditis group during acute phase was(76.81±11.05) μmol/L,which was significantly lower than those in control group [(116.28±11.76) μmol/L] and viral myocarditis group during recovery phase [(89.75±9.90) μmol/L](P<0.01).There was a significant negative correlation between nitric oxide and zinc in viral myocarditis group during acute phase(P<0.05).Conclusion:The changes of serum nitric oxide and zinc levels are correlated with the occurrence and development of viral myocarditis.