新生儿败血症患儿血清降钙素原及白介素-6水平变化研究

目的:探讨血清降钙素原及白介素-6水平在新生儿败血症早期诊断中的价值。方法:选择40例败血症新生儿及40例健康新生儿作为研究对象,测定败血症组急性期、恢复期及健康对照组血清降钙素原及白介素-6水平。结果:败血症组急性期血清降钙素原及白介素-6水平显著高于对照组(P<0.05)。败血症组恢复期和对照组血清降钙素原及白介素-6水平比较,差别无统计学意义(P>0.05)。败血症组急性期血清降钙素原及白介素-6水平显著高于恢复期(P<0.05)。结论:血清降钙素原及白介素-6水平和新生儿败血症严重程度呈正相关性,血清降钙素原及白介素-6水平可作为新生儿败血症早期诊断及评价预后的重要指标。

Study on the changes of serum procalcitonin and interleukin-6 levels among the neonates with sepsis

Objective:To explore the values of serum procalcitonin and interleukin-6 levels in early diagnosis of neonatal sepsis.Methods:Forty neonates with sepsis and forty healthy neonates were selected as research objects,the serum procalcitonin and interleukin-6 levels during acute phase and recovery phase in sepsis group and control group were detected.Results:The serum procalcitonin and interleukin-6 levels during acute phase in sepsis group were significantly higher than those in control group(P<0.05).There was no significant difference in the serum procalcitonin and interleukin-6 levels between recovery phase in sepsis group and control group(P>0.05).The serum procalcitonin and interleukin-6 levels during acute phase in sepsis group were significantly higher than those during recovery phase in sepsis group(P<0.05).Conclusion:There is a positive correlation between serum procalcitonin and interleukin-6 levels and the degree of severity of neonatal sepsis,serum procalcitonin and interleukin-6 levels can be used as important indexes for early diagnosis and evaluation of prognosis in the neonates with sepsis.