糖尿病心肌离子通道重构的研究进展

糖尿病心血管并发症是患者死亡的主要原因,其中重要的临床表现是与猝死相关的心律失常发生率较高。糖尿病患者心电图常出现与心律失常相关的QT间期延长,且心电图的异常可不伴随其它危险因素而独立存在。实验研究也显示糖尿病动物模型的QT间期延长对应心室肌细胞动作电位时

Recent advance in cardiac ion channel remodeling in diabetes

Occurrence of lethal cardiac arrhythmia,which is associated with prolongation of the QT interval in electrocardiogram(ECG),is related to increased mortality in the patients with diabetes mellitus(DM).Increased QT interval reflects the prolonged cardiac action potential duration(APD).APD abnormality is based on by cardiac ion channel remodeling induced by DM-related pathological changes.As DM is becoming an important risk factor for atrial fibrillation,the most clinically common arrhythmia,this review mainly summarizes the alterations of ion channel currents and relevant protein expression in diabetic ventricular myocytes to explore the underlying mechanisms of arrhythmia,and also discusses some research achievements from investigating the atrial myocytes in DM,