| 丹贝和大豆异黄酮提取物对小鼠移植性肿瘤抑制作用的研究 |
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| 引用本文： | 翟成凯,高霞,孙桂菊,蒋兆坤,江汉湖,陆琮明,张小强.丹贝和大豆异黄酮提取物对小鼠移植性肿瘤抑制作用的研究[J].东南大学学报(医学版),2000,19(4):219-220. |
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| 作者姓名： | 翟成凯 高霞 孙桂菊 蒋兆坤 江汉湖 陆琮明 张小强 |
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| 作者单位： | 1. 南京铁道医学院公共卫生学院，江苏 南京 210009
2. 南京农业大学食品科技学院，江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金资助项目(39470610) |
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| 摘 要： | 目的研究丹贝及大豆异黄酮提取物对小鼠移植性肿瘤的抑制作用和对免疫功能的影响。方法观察受试物对BALB/C小鼠移植肉瘤(S-180)的作用和对单核巨噬细胞功能的影响，检测小鼠胸腺、脾指数的变化。结果11.42g·kg-1的丹贝异黄酮提取物能抑制S180生长，此剂量及5.71g·kg-1的剂量能抑制胸腺指数下降，提高单核巨噬细胞吞噬功能。结论丹贝异黄酮提取物可望成为具有抑制肿瘤作用的保健食品。
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| 关 键 词： | 丹贝 大豆 异黄酮 抗肿瘤 免疫 小鼠 |
| 文章编号： | 1001-7275(2000)04-0219-03 |
| 修稿时间： | 2000年8月25日 |
Study on the Inhibitory Effect of Tempe and Soybean Isoflavone Extract on Transplanted Tumour in Mice |
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| ZHAI Cheng-kai,GAO Xia,SUN Gui-ju,JIANG Zhao-kun,JIANG Han-hu,LU Cong-ming,ZHANG Xiao-qiang.Study on the Inhibitory Effect of Tempe and Soybean Isoflavone Extract on Transplanted Tumour in Mice[J].Journal of Southeast Univ: Medical Sci Ed,2000,19(4):219-220. |
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| Authors: | ZHAI Cheng-kai GAO Xia SUN Gui-ju JIANG Zhao-kun JIANG Han-hu LU Cong-ming ZHANG Xiao-qiang |
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| Abstract: | Objective To observe the effects of tempe and soybean isoflavone extract on an titumor and immunoreaction.Methods The effects on tumor weight, thymus and spleen index and macrophage activities were examined of mice carried S180. Results Tempe isoflavone extract(11.42g·kg-1) can inhibite the growth oftumour (S-180) of BALB/C mice carried.Tempe isoflavone extract 11.42 g,5.71 g· kg-1 can inhibite the drop of thymus index and improve the activities of macrophage of mononuclear phagocyte in mice carried S-180. Conclusion Tempe isoflavone extract will become a functional food with antitumor activity. |
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| Keywords: | tempe soybean isoflavone antitumor immunity mice |
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