慢性乙型肝炎病毒携带者的肝组织病理分析

目的对178例年龄在12～40岁之间的慢性HBV携带者与非活动性HBsAg携带者肝组织病理结果进行分析。方法178例分为<20岁、<30岁、<40岁三个年龄组,分别观察三个年龄组间肝组织炎症活动度及纤维增生的分布情况及差异性。结果>G2/S2的分布为<20岁年龄组(14%),<30岁年龄组(41%),<40岁年龄组(80%)。随年龄增长,肝组织损伤的程度呈加重趋势,差异有显著性(P<0.05)。不同年龄与病毒基因水平,肝组织病变程度与病毒基因水平之间差异无显著性(P>0.05)。慢性HBV携带者与非活动性HBsAg携带者之间肝组织病变差异有显著性(P<0.05)。结论对上述两种携带者,有条件时最好行肝活检,以早期发现适宜治疗者而避免延误病情。对两者间的治疗应有所侧重。

Analysis of liver biopsy in chronic hepatitis B virus carriers

Objective To explore 178 cases(ranging from 12 to 40 years) of liver fine needle aspiration biopsy in patients with chronic HBV carriers and chronic inactive HBsAg carriers. Method All 178 cases divided into three groups: less than 20 years old, less than 30 years old, less than 40 years old. Respectively comparative hepatic tissue inflammation degree and distribution of fibber length among three groups. Results >G2/S2 among all patients: less than 20 years old were 14%;less than 30 years old were 41%;less than 40 years old were 80%.The liver injury aggravation exit with increase of age tendency. Existing significant difference (P<0.05). In different age and virogene levels, degree of liver injury and virogene levels had no significant difference (P>0.05 ). Hepatic tissue result in both the chronic HBV carrier and chronic inactive HBsAg carrier had significant difference (P<0.05 ). Conclusions Two kinds of virus carriers need to being liver fine needle aspiration biopsy at the earliest opportunity, so that discovering therapy opportunity for delay condition advancement. Different treatment be used in the chronic HBV carrier and chronic inactive HBsAg carrier.