| 铅中毒大鼠排泄物中微量元素硒的初步研究 |
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| 引用本文： | 刘景英,胡秀丽,刘忠英,李才. 铅中毒大鼠排泄物中微量元素硒的初步研究[J]. 微量元素与健康研究, 2005, 22(6): 1-3 |
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| 作者姓名： | 刘景英 胡秀丽 刘忠英 李才 |
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| 作者单位： | 吉林大学再生医学科学研究所,长春,130021 |
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| 基金项目： | 吉林省科技厅资助项目[20020503-4] |
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| 摘 要： | 目的:探讨铅中毒对大鼠全血、粪便和尿液中微量元素铅和硒的影响。方法:Wistar大鼠随机分为对照组和铅中毒组。大鼠饮服0.2%醋酸铅水溶液3周,造成实验性铅中毒后,采集全血、粪便和尿液。用原子吸收分光光度法测定铅含量,荧光分光光度法测定硒含量。结果:与对照组相比,铅中毒组大鼠全血、粪便和尿液中铅含量均显著升高(P<0.01),全血和尿液中硒含量亦明显升高(P<0.05),粪便中硒含量明显降低(P<0.01)。结论:铅中毒引起微量元素硒排出,为预防铅中毒,应增加膳食中硒摄入水平。
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| 关 键 词： | 硒 铅 铅中毒 |
| 文章编号： | 1005-5320(2005)06-0001-03 |
| 收稿时间： | 2005-07-21 |
| 修稿时间： | 2005-07-21 |
Study on Trace Element Selenium of Excretion in Lead-treated Rats |
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| LIU Jing- ying,HU Xiu- li,LIU Zhong- ying,et al. Study on Trace Element Selenium of Excretion in Lead-treated Rats[J]. Studies of Trace Elements and Health, 2005, 22(6): 1-3 |
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| Authors: | LIU Jing- ying HU Xiu- li LIU Zhong- ying et al |
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| Affiliation: | Institute of Frontier of Medical Science, jilin University Changchun 130021, China |
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| Abstract: | Objective:To investigate the changes of the contents of lead and selenium in the whole blood,faeces and urine of rats with lead poisoning.Methods: Wistar rats were randomly divided into control group and poisoning group.The rats were fed with 0.2g/L lead acetate solution by drinking for three weeks.After the rats were poisoned,the rats' whole blood,faeces and urine were collected.Lead content was determined by flame atomic absorption spectrophotometry and selenium content was analyzed by fluorometric spectrophometry.Results:Compared with the control group,the lead content in the rats' whole blood,faeces and urine of the poisoning group was significantly higher(P<0.01),selenium content in the whole blood and urine was significantly higher(P<0.05),while in the faeces was significantly lower(P<0.01).Conclusion:Lead poisoning induced selenium excretion.To prevent lead poisoning,the selenium intake should be elevated. |
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| Keywords: | Selenium Lead Lead poisoning |
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