| 三种蒽醌衍生物对小鼠外周血淋巴细胞微核影响 |
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| 引用本文： | 程龙球,梁志成,汝明权. 三种蒽醌衍生物对小鼠外周血淋巴细胞微核影响[J]. 癌变．畸变．突变, 2000, 12(1): 45-47 |
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| 作者姓名： | 程龙球 梁志成 汝明权 |
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| 作者单位： | 暨南大学生物工程学系!广东广州510632(程龙球，梁志成)，山东医科大学生物教研室!山东济南250012(汝明权) |
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| 摘 要： | 目的：探讨１．５－二氨基蒽醌（１．５－ＤＡＡＱ）、１．５－二氯蒽醌（１．５－ＤＣＡＱ）和１．８－二氯蒽醌（１．８－ＤＣＡＱ）的遗传毒理。方法：本文运用小鼠外周血淋巴细胞微核测定方法。结果：小鼠第一次被注射１．５－ＤＡＡＱ，１．５－ＤＣＣＱ和１．８－ＤＣＡＱ所产生的微核细胞与空白对照相经无显著性差异，第二次以及以后各次分别注入上述三种化合物时，与对照组相比有显著差异（Ｐ〈０．０１）。结论：三种ＡＱｓ
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| 关 键 词： | 蒽醌衍生物 遗传毒理 微核率 外周血淋巴细胞 |
| 文章编号： | 1004-616X(2000)01-0045-02 |
| 修稿时间： | 1999-02-17 |
EFFECTS OF SOME ANTHRAQUINONE DERIVATIVES ON MOUSE PERIPHERAL BLOOD LYMPHOCYTE MICRONUCLEUS |
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| Abstract: | Purpose and Methods: Most of the information about possible genotoxic effects of anthraquinone derivatives is derived from prokaryotic systems that must differ from mammalian systems and human. In this study 1.5-diaminoanthraquinone(1.5-DAAQ), 1.5-dichloroanthraquinone(1.5-DCAQ) and 1.8-diahloroanthraquinone(1.8-DCAQ) were selected for testing used micronucleus(MN) analysis in BALBC/c mice peripheral blood lymphocytes. Results: Results show that they were significant difference from second to fifth injection times as compared with the control micronucleus frequency (P<0.01) when those compounds accumulated to a weight of 100mg/kg.bw following ip in BALBC/c mice. Conclusion: We suggest there is requirement to research and minitor their mutagenesis. |
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| Keywords: | anthraquinones derivative genotoxicity micronucleus |
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