| Institution: | (1) Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako Saitama, 351-0198, Japan;(2) Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan;(3) Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan;(4) Department of Psychiatry and Neurobiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;(5) Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan;(6) Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan;(7) Department of Psychiatry, Health Service Center, University of Tokyo, Tokyo, Japan;(8) Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo, Japan;(9) Department of Physiology, Keio University School of Medicine, Tokyo, Japan;(10) Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan |
| Abstract: | Pathophysiological role of endoplasmic reticulum (ER) stress response signaling has been suggested for bipolar disorder. The
goal of this study was to test the genetic association between bipolar disorder and an ER chaperone gene, HSP90B1 (GRP94/gp96), which is located on a candidate locus, 12q23.3. We tested the genetic association between bipolar disorder and HSP90B1 by case-control studies in two independent Japanese sample sets and by a transmission disequilibrium test (TDT) in NIMH Genetics
initiative bipolar trio samples (NIMH trios). We also performed gene expression analysis of HSP90B1 in lymphoblastoid cells. Among the 11 SNPs tested, rs17034977 showed significant association in both Japanese sample sets.
The frequency of the SNP was lower in NIMH samples than in Japanese samples and there was no significant association in NIMH
trios. Gene expression analysis of HSP90B1 in lymphoblastoid cells suggested a possible relationship between the associated SNP and mRNA levels. HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to
understand the underlying functional mechanisms. |
