| HAART对血清中可溶性白介素-2受体水平的影响 |
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| 引用本文： | 孙桂珍,张洪海,张彤. HAART对血清中可溶性白介素-2受体水平的影响[J]. 中华实验和临床病毒学杂志, 2008, 22(3) |
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| 作者姓名： | 孙桂珍 张洪海 张彤 |
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| 作者单位： | 首都医科大学附属北京佑安医院临床检验中心,100069 |
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| 摘 要： | 目的 探讨高效抗逆转录病毒治疗(HAART)对血清中可溶性白介素·2受体(slL-2R)水平的影响.方法 收集90例接受HAART前后AIDS患者的血清和抗凝全血,用酶联免疫吸附试验(ELISA)检测血清sIL-2R水平,用流式细胞术检测患者外周血T淋巴细胞亚群计数,利用bDNA定量法检测病毒载量(VL).结果 HAART治疗前slL-2R平均水平为(3154 4-905)p9/ml,治疗后平均水平降至(2216 4-884)pg]ml(P<0.001).治疗后HAART无效组sIL-2R平均为(2846.4-963)pg/ml,有效组平均为(1879.4-875)p9/ml(P<0.001).结论 有效的HAART明显降低血清中slL-2R水平,且slL-2R水平具有一定的疗效判断作用.
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| 关 键 词： | 获得性免疫缺陷综合征 受体,白细胞介素-2 酶联免疫吸附测定 |
The effect of HAART to serum soluble interleukin-2 receptors in AIDS patients |
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| SUN Gui-zhen,ZHANG Hong-hai,ZHANG Tong. The effect of HAART to serum soluble interleukin-2 receptors in AIDS patients[J]. Chinese journal of experimental and clinical virology, 2008, 22(3) |
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| Authors: | SUN Gui-zhen ZHANG Hong-hai ZHANG Tong |
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| Abstract: | Objective To approach the effect of HAART to serum soluble interleukin-2 receptors in AIDS patients. Methods 90 cases of AIDS patients were chosen for detection of their slL-2R levels by enzyme-linked immunosorbent assay (ELISA), peripheral blood CD4+ T cell counts by flow cytometry and viral load by Branch DNA amplification. Results The slL-2R levels were (3154±905)pg/ml before HAART and (2216±884)pg/ml after (P<0.001), After HAART, the slL-2R levels were (2846±963) pg/ml in ineffective HAART group and (1879±875)pg/ml in effective HAART group (P<0.001). Conclusion The serum slL-2R levels of AIDS patients were lowered by effective HAART, and it could judge the efficacy of HAART in same extent. |
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| Keywords: | Acquired immunodeficiency syndrome Receptors,interleukin-2 Enzyme-linked immuosorbent assay |
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