177例毒瘾者丙型肝炎病毒感染的流行病学调查

采取ELISA法对167例静脉内毒瘾者、10例口吸毒瘾者、49例非肝病病人及58例供血员作了抗-HCV检测。结果发现,抗-HCV阳性率分别为92.2%、10%、2.0%和1.7%,静脉内毒瘾者的HCV感染率非常显著高于其他各组(P<0.001),后3组之间差异无显著意义(P>0.05)。表明静脉内毒瘾者是HCV感染的高危人群,造成该人群HCV感染的流行可能与HCV感染者合用注射器静注毒品、注射器和毒品溶剂不消毒等因素有关,与用毒时间无显著相关。HCV感染在不同特征的静脉内毒瘾者的分布是一致的。

Prevalence of Antibody to Hepatitis C Virus in 177 Drug Addicts

Antibody to hepatitis C virus (anti-HCV) was measured by enzyme-linked immunosorbent assay (ELISA) in 167 intravenous drug addicts, 10 oral drug addicts, 49 patients without liver disease and 58 blood donors. It was found that the prevalent rate of anti-HCV in these groups were 92.2%, 10%, 2.0% and 1.7%, respectively. It is also noted that the prevalence of anti-HCV for intravenous drug addicts was significantly higher than that for oral drug addicts, patients without liver disease, and blood donors (P<0.001). There was no significant difference among the later three groups. It isindicated that intravenous drug addicts are high-risk group of HCV infection. Injecting drug with injectors of HCV carrier, injectors and/or solvent not being sterilized may contribute to prevalence of HCV in these groups. It is similar that the distributions of HCV infection in intravenous drug addicts with different trait.