血清胆固醇与癌症死亡率的前瞻性定群研究

对70年代调查测定血清胆固醇等的9021名35~64岁工厂职工平均随访11年。共64人失访、595人死亡,其中癌症263人,原发性肝癌51人。将对象按基线检查时血清胆固醇值的高低分成人数相似的4组。用Log-rank趋势检验法未发现血清胆固醇水平与总的恶性肿瘤死亡的联系,但血清胆固醇值与肝癌存在显著的负相关(P<0.05)。用Cox多变量回归分析表明此负相关独立于其他因素(Z=-2.18, P<0.05),且除去14名死于基线调查三年内的肝癌后,此负相关依然存在。血清胆固醇与慢性肝炎及肝硬化死亡也有类似的负相关。乙肝感染能否缓慢降低血清胆固醇水平,值得进一步探讨。

Serum Cholesterol and Cancer Mortality: Eleven-Year Prospective Cohort Study on More Than 9 Thousand Persons

Nine thousand and twenty-one employees aged 35-64 years were investigated in the 70s in the meantime with serum cholesterol and other measurements takan, and followed up for 11 years on the average. There were 595 deaths and 64 loss of follow-up. The total number of cancer death was 263 that of primary liver cancer was 51.
Subjects were divided into 4 similar sized groups according to serum cholesterol level at basal measurement. No evidence of association of serum cholesterol level with total cancer mortality was seen by Log-rank trend test. But negative correlation was significant between serum cholesterol level and liver cancer (P<0.05). By Cox regression analysis such negative correlation was found to be independent of other variables (Z=-2.18, P<0.05). This negative correlation persisted even after 14 deaths of primary liver cancer which occurred within 3 years after measurement of serum cholesterol was discounted. Similar negative correlation also existed between serum cholesterol level and chronic hepatitis and liver cirrhosis.