HBV基因分型方法在家系传播研究中的应用

本文报告了河北省一个自然村乙型肝炎的血清流行病学研究结果。HBsAg阳性率为3.75%,HBV总感染率为27.65%,属于低发区;其成因可能与人群特征(献血员占多数)和HCV感染率高(10.31%)有关。经二项分布拟合分析,抗-HBc和HBV总感染率有家庭聚集性,并且主要是父母对其子女的传播和子女之间的水平传播所致。HBV DNA阳性率为24.77%(27/109),大多数(72.22%)家庭成员感染者之间为同一HBV基因型。在HBV亚型基因分类的基础上,将HBV的家庭传播划分为家系世代、水平、隐性、内外混合传播型和家系不传播型及未定型等六种。

Application of HBV Gene Subtyping Method in Study on Familial Transmission

A cross-section epidemiological study for hepatitis B was conducted in the population of a village in Hebei Province. The prevalence rate of HBsAg was 3.75% (22/586), and HBV infection rate, 27.65% (162/586), without significant difference between males and females; and increasing with age.This village belongs to a low HBV incidence region in China. This phenomenon might possibly be related to the characteristic of the population (mostly blood donors) and high incidence of HCV (prevalence rate of anti-HCV was 10.31%, 59/572). The anti-HBc and overall HBV infection rate showed family clustering by binomial distribution analysis. The family clustering of HBV infection resulted mainly from the transmission from parents to their children and among the children. The overall positivity rate of HBV DNA was 24.77% (27/109), and the majority of the family members belonged to the same subtypes (72.22%). On the basis of HBV subtyping, familial transmission of HBV was classified into six types, ie.generational, horizontal, recessive, intra-and extra-familial, non-familial and undetermined ones.