我国吸烟与肺癌关系的Meta-analysis——15个病例对照研究的合并分析

应用Ｍｅｔａ－ａｎａｌｙｓｉｓ方法对国内１５个有关吸烟与肺癌病例对照研究进行了定量综合分析。累积病例为５７０３例，对照为５６６９例。采用Ｐｅｔｏ氏和Ｄｅｒｓｉｍｏｎｉａｎ ａｎｄ Ｎａｎ Ｌａｉｒｄ二氏模型方法处理数据。吸烟因素合并ＯＲ（吸烟与不吸烟对比）在男性为３．０１（２．６３～３．４６），ＰＡＲ为５６．８４％；而在女性合并ＯＲ为２．３２（２．０２～２．６６），ＰＡＲ为３３．１０％、吸烟量、吸

Meta-analysis of Smoking and Lung Cancer in China: Combined Analysis of Fifteen Case-control Studies

In the present paper, 15 case-control studies on the relation between smoking and lnng cancer in China were analyzed by means of Meta-analysis method, The cumulative cases and controls were 5703 and 5669, respectively. Peto''s model and Der Simonian and Nan Laird model were applied to process data. The pooled OR (smoking vs no smoking) was 3.01 (95%CI:2.63~3.46) in males and 2.32 (95% CI:2.02~2.66) in females. The PAR was 56.84% in males and 33.10% in females. There was significant dose-response relation between the amount of smoking, the years of smoking, the age at start of smoking and the OR for developing lung cancer. The pooled OR of squamous carcinoma was 4.79 (95%CI:4.02~5.70), PAR was 65.44%. The pooled OR of adenocarcinoma was 1.02 (95%CI:0.87~1.20), PAR was 0.99%.