| 普伐他汀调脂过程中P-选择素表达的变化 |
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| 引用本文： | 尹松梅,马丽萍,徐立卓. 普伐他汀调脂过程中P-选择素表达的变化[J]. 中华血液学杂志, 1998, 19(9): 461-463 |
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| 作者姓名： | 尹松梅 马丽萍 徐立卓 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院，珠海市拱北医院 |
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| 基金项目： | 广东省自然科学基金,广东省卫生厅科研基金 |
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| 摘 要： | 目的：探讨普伐他汀促进动脉粥样硬化斑块消退的机制。方法：观察高胆固醇血症患者经普伐他汀１０～２０ｍｇ／ｄ治疗４周及８周后血小板功能和血脂的变化。结果：治疗４周及８周后血胆固醇降低，同时每个血小板膜表面Ｐ选择素的分子数由治疗前的７４８±１５４分别降至４７８±１１０和３７８±１１９；血浆Ｐ选择素由治疗前的２４．３±９．９μｇ／Ｌ分别降至１６．８±４．５和１６．１±４．０μｇ／Ｌ，血小板膜表面和血浆Ｐ选择素之间显示较好的相关性（ｒ＝０．８７２２）。结论：普伐他汀促进动脉粥样硬化斑块消退的早期效益是由于对血小板功能的良性影响而产生。
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| 关 键 词： | P-选择素 普伐他汀 高胆固醇血症 |
Influence of pravastatin therapy on expression of P selectin |
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| Yin Songmei,Ma Liping,Xu Lizhuo,et al.. Influence of pravastatin therapy on expression of P selectin[J]. Chinese Journal of Hematology, 1998, 19(9): 461-463 |
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| Authors: | Yin Songmei Ma Liping Xu Lizhuo et al. |
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| Affiliation: | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen Medical University, Guangzhou 510120. |
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| Abstract: | OBJECTIVE: To study the mechanism of pravastatin enhancing atherosclerosis regression. METHODS: Patients with hypercholesterolemia were treated with pravastatin 10-20 mg/d for 4 and 8 weeks. The changes of blood cholesterol and platelet functions were examined. RESULTS: After 4 weeks and 8 weeks treatment, the expression of platelet membrane P-selectin was decreased from 748 +/- 154 molecular number(MN)/platelet to 478 +/- 110 MN/platelet and 378 +/- 119 MN/platelet, respectively, plasma P-selectin was decreased from 24.3 +/- 9.9 micrograms/L to 16.8 +/- 4.5 and 16.1 +/- 4.0 micrograms/L, respectively, correlative with the lowering of blood cholesterol. Platelet P-selectin was positively correlated with plasma P-selectin(r = 0.8722). CONCLUSION: The early benefit of pravastatin in enhancing atherosclerosis regression was partly due to the improvement of platelet function. |
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| Keywords: | P selectin Pravastatin Hypercholesterolemia |
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