蛋白质组学在肺癌诊治研究中的应用

随着人类基因组计划的完成,双向凝胶电泳和质谱的应用以及生物信息学的引入,蛋白质组学的研究获得了极大发展.肿瘤蛋白质组学从新的角度研究肿瘤,寻找肿瘤标志蛋白,进而阐明其表达水平的变化与肿瘤发生、发展的相互关系,对肿瘤的早期诊断、治疗、药物研发等方面具有重要意义.本文就蛋白质组学的相关技术、策略及其在肺癌研究中的应用作一简要综述.

Application of proteomics to diagnosis and treatment of lung cancer

With the completion of human genome sequence project (HGP), the application of two-dimensional gel electrophoresis (2-DE), mass spectrometry (MS), and bioinformatics, more achievements have been made in proteomics research. From the new point of view, looking for tumor-specific proteins with proteomics research strategy may help to elucidate the correlation of the change of protein expression to oncogenesis, and may play a vital role in the early detection of cancer and anticancer therapy including drug exploitation. This article briefly reviewed the relevant techniques, strategies, and application of proteomics research on lung cancer.