Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation |
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| Authors: | Jussi Hirvonen Anne Roivainen Jere Virta Semi Helin Kjell Någren Juha O Rinne |
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| Institution: | (1) Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, 20521 Turku, Finland |
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| Abstract: | Purpose The positron emission tomography (PET) radiotracer 11C-(R)-PK11195 allows the in vivo imaging in humans of the translocator protein 18 kDa (TSPO), previously called peripheral benzodiazepine
receptor (PBR), a marker of inflammation. Despite its widespread use, the radiation burden associated with 11C-(R)-PK11195 in humans is not known. To examine this, we performed dynamic whole-body imaging with PET and 11C-(R)-PK11195 in healthy humans. |
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