缺氧性肺动脉高压大鼠肺血管内皮细胞的变化

３０只雄性Ｗｉｓｔａｒ大鼠随机分成正常对照和缺氧１、２、３、４周组（共５组），吸入１０％Ｏ＿２，９０％Ｎ＿２，每天８ｈ，每周６天。静注１％ＦｅＣｌ３０．２ｍｌ／１００ｇ体重，每周２次。于缺氧１、２、３、４周未测肺动脉压力，取肺动脉及肺组织行电镜检查，结果显示：缺氧时间越长，肺血管内皮细胞结构损伤越重，肺动脉压力越高。提示血管内皮细胞损伤在肺动脉高压形成中起重要作用。

The changes of pulmonary vascular endothelial cells in hypoxic hypertension rats

The changes of vascular endothelial cells was observed 30 male Wistar ratswere randomly divided into 5 groups.They were control group and groups ofhypoxic 1,2,3,4 weeks respectively.Rats were eyposed to 10% O2,90% N2,injected 0.2ml/ 100g 1 % FeC13. When the treatment time was over, the PaO2 and pulmonaryhaemodvnamics were measured,pulmonary artery and lung specimens were examined byscaning electron micrography(SEM) and transmission electron micrography(TEM).The results show that:(1) The pulmonary artery pressure(PAP) of hypoxic rats in-creased,the longer the hpyoxic time,the higher the PAP,(2)The hypoxic rats had obvi-ous anoxia.(3)The pulmonary VEC were damagedobviously.After 1 week hypoxia,the pulmonary VEC appeared swollen,and the mitochondria were also swollenAs thetime goes on, the VEC appeared splitting,broken and peeled off, the basel laminaparted,the collagen in basal lamina increased obviously.