| 甘氨酸对内毒素致热性的抗拮作用研究 |
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| 引用本文： | 陆大祥 李楚杰. 甘氨酸对内毒素致热性的抗拮作用研究[J]. 中国病理生理杂志, 1996, 12(3): 235-238 |
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| 作者姓名： | 陆大祥 李楚杰 |
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| 作者单位： | 暨南大学医学院病理生理教研室 |
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| 摘 要： | 本研究用新西兰家兔４２只，分为７组，观察不同剂量甘氨酸对内毒素致热性的灭活效果。
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| 关 键 词： | 甘氨酸 内毒素 体温 |
Inhibitory effect of glycine upon endotoxin pyrogenicity |
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| LuDa-Xiang,Li Chu-Jie,Fu Yong-Mei,Wang Hua-Dong. Inhibitory effect of glycine upon endotoxin pyrogenicity[J]. Chinese Journal of Pathophysiology, 1996, 12(3): 235-238 |
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| Authors: | LuDa-Xiang Li Chu-Jie Fu Yong-Mei Wang Hua-Dong |
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| Abstract: | Inhibitory effect of glycine(G)upon endotoxin(ET) pyrogenicity was observed in 42 new zeland rabbits.The results showed:(1)pyrogenicity of ET was inhibited significantly when the ratio of G to ET was 10mg:100U,and the biphasic fever was changed into monophasic fever.(2)The pyrogenicity of ET was futher reduced when the ratio of G to ET was 50mg:100U,and there was only a small and low monophase in thermo-response curve.(3)the pyrogenicity of ET wasinhibited nearly completed when the ratio of G to ET was 200mg:100U,and there was no significant raising phase in thermo-response curve.(4)G alone did not affect the normal body temperature.(5)there was no effect of G on ET pyrogenicity when it was administrated 5min after injecting of ET.It was suggested that G can inhibite the pyrogenicity of ET markedly and is a very promising ET antagonist. |
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