非饮食因素与胃癌关系的病例对照研究

目的探讨非饮食因素与胃癌发病的关系，为胃癌的有效预防提供依据。方法采用统一问卷调查表，调查189例胃癌患者和567例对照人群，调查内容包括一般情况、胃癌发病前5年及10年的住房和收入状况、生活习惯、是否补充维生素、是否使用冰箱、吸烟和饮酒史、既往胃病史、肿瘤家族史等。对问卷调查结果进行单因素和多因素Logistic回归分析，计算各因素与胃癌联系的比值比(OR)及其95％可信区间(95％CI)、P值等。结果社会经济状况好(高学历、白领职业、人均收入高、住房面积大)、使用冰箱、补充维生素、饮绿茶等与胃癌的危险性呈负相关；吸烟、饮白酒、胃癌或肿瘤家族史、既往胃病史等与胃癌的发生呈正相关。结论社会经济水平高、使用冰箱、补充维生素、饮绿茶等为胃癌的保护因素；吸烟、饮白酒、胃癌或肿瘤家族史、既往胃病史等为胃癌的危险因素。努力提高人们的社会经济水平、增加冰箱的使用率、适当补充维生素、常饮绿茶、戒除烟酒等可能是预防胃癌的有效手段。

Non-dietary factors and gastric cancer:a case-control study

Objective To investigate the relationship between non-dietary factors and the development of gastric cancer. Methods 189 patients with gastric cancer and 567 controls were matched to make a survey with a questionnaire, which consisted of demography, housing and income 5 and 10 years prior to the onset of gastric cancer, lifestyle, use of home refrigerator, smoking and alcohol drinking, past history of gastric diseases, family history of cancer, etc. SPSS software package was used to perform the univariate and multivariate Logistic regression analysis to calculate the OR of the relationship between each variate and gastric cancer, and their 95% CI and P value. Results High socio-economic status, use of refrigerator, supplement of vitamins, and green tea were inversely associated with gastric cancer, while smoking and alcohol drinking, family history of cancer and chronic gastric diseases were positively related to the risk of gastric cancer. Conclusion These findings illustrate that high socio-economic status, use of refrigerator, supplement of vitamins and green tea are protective factors against gastric cancer, and smoking and alcohol drinking, family history of cancer and chronic gastric diseases are risk factors of gastric cancer.