人附睾分泌蛋白4与糖类抗原125联合测定在盆腔肿瘤诊断中的意义

目的：探讨人附睾分泌蛋白4（HE4）与糖类抗原125（CA125）联合测定在卵巢和子宫肿瘤的诊断价值。方法分别采用酶联免疫吸附法和电化学发光免疫测定112例卵巢癌、92例子宫癌、145例卵巢良性病变、138例子宫肌腺瘤以及56例健康女性的血清HE4和CA125水平。结果盆腔良恶性肿瘤血清HE4和CA125水平比较，卵巢恶性肿瘤组[HE4（246．80＆#177;52．81） pmol/L、CA125（439．20＆#177;305．80）U/mL]、子宫恶性肿瘤组[HE4（196．50＆#177;38．15）pmol/L、CA125（463．80＆#177;127．60）U/mL]与对照组[HE4（19．76＆#177;16．45）pmol/L、CA125（15．67＆#177;11．19）U/mL]比较，差异有统计学意义（P＜0．05）；卵巢癌组和子宫癌组术前与术后2周HE4和 CA125水平分别比较，差异有统计学意义（P＜0．05）。结论联合检测血清 HE4和CA125水平可以提高诊断盆腔肿瘤的灵敏度和准确度。

Significance of combined detection of human epididymal secretory protein 4 and carbohydrate antigen 125 in diagnosing pelvic tumor

Objective To investigate the value of the combined detection of serum human epididymal secretory protein 4（HE4） and carbohydrate antigen 125（CA125） in diagnosing ovarian and uterine tumor .Methods Serum levels of HE4 and CA125 were detected in 112 cases of ovarian cancer ,92 cases of uterine cancer ,145 cases of ovarian benign diseases ,138 cases of uterine adeno-myoma and 56 cases of healthy controls by ELISA and electrochemiluminescence（ECL） immunoassay respectively .Results Serum levels of HE4 and CA125 were （246 .80 ＆#177; 52 .81）pmol/L and （439 .20 ＆#177; 305 .80）U/L in the ovarian malignant tumor group , （196 .50 ＆#177; 38 .15）pmol/L and （463 .80 ＆#177; 127 .60） U/mL in the uterine malignant tumor group and （19 .76 ＆#177; 16 .45）pmol/L and （15 .67 ＆#177; 11 .19）U/mL in the control group ,the differences had statistical significance （P＆lt;0 .05） .Serum levels of HE4 and CA125 before operation and in postoperative 2 weeks in the ovarian cancer group and the uterine cancer group had statistical difference （P＆lt;0 .05） .Conclusion The combination detection of serum HE4 and CA125 can improve the accuracy and sensitivity in the diag-nosis of pelvic tumors .