| 2型糖尿病患者单核细胞-内皮粘附功能的改变(摘要) |
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| 引用本文： | 李伟,Tomoko Asagami,Fahim Abbasi,Cindy Lamendola,Philip S Tsao,Gerald M Reaven.2型糖尿病患者单核细胞-内皮粘附功能的改变(摘要)[J].海南医学,2002,13(11). |
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| 作者姓名： | 李伟 Tomoko Asagami Fahim Abbasi Cindy Lamendola Philip S Tsao Gerald M Reaven |
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| 作者单位： | 1. 海南省人民医院内科,海口,570311
2. 美国斯坦福大学医学院心血管研究中心,加州斯坦福,94305 |
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| 摘 要： | 目的 :观察 2型糖尿病人外周血单个核细胞对培养的血管内皮细胞的粘附性。方法 :采用单核细胞 -内皮细胞粘附试验检测 5 2例 2型糖尿病患者、3 2例健康志愿者的单核细胞 -血管内皮粘附功能。结果 :(1)糖尿病组外周血单个核细胞 -内皮细胞粘附率显著高于正常对照组 (P <0 .0 0 1) ,(2 )经多元回归分析 ,空腹血糖与单核细胞粘附率存在独立的相关关系 (P <0 .0 0 1)。结论 :2型糖尿病人外周血单个核细胞对培养的血管内皮细胞粘附性增强 ,高血糖等代谢异常与此粘附性增强有关。
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| 关 键 词： | 2型糖尿病 单核细胞-内皮细胞粘附 |
Changes of adherence of mononuclear cells to endothelium in patientswith type 2 diabetes mellitus |
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| Tomoko Asagami,Fahim Abbasi,Cindy Lamendola,Philip S Tsao,Gerald M Reaven.Changes of adherence of mononuclear cells to endothelium in patientswith type 2 diabetes mellitus[J].Hainan Medical Journal,2002,13(11). |
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| Authors: | Tomoko Asagami Fahim Abbasi Cindy Lamendola Philip S Tsao Gerald M Reaven |
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| Abstract: | Objective:To investigate the adherence of mononuclear cells to endothelium in patients with type 2 diabetes mellitus. Methods: Endothelial adhesiveness for mononuclear cell was assessed by functional binding assay in 52 type 2 diabetic patients and 32 healthy volunteers. Results: Adherence of mononuclear cells from patients with type 2 diabetes mellitus was significantly greater than that of cells isolated from the healthy volunteers (P<0.001). Multiple regression analysis demonstrated an independent relationship between mononuclear cell binding and fasting plasma glucose(P<0.001). Conclusion: Adherence of mononuclear cells to endothelium is increased in patients with type 2 diabetes mellitus. Hyperglycemia, or other metabolic abnormalities, is responsible for the enhanced adhesiveness of mononuclear cells. |
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| Keywords: | type 2 diabetes mellitus Adherence of mononuclear cells to endothelium |
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