Management of intraductal papillary mucinous neoplasm of the pancreas |
| |
Authors: | Masanori Sugiyama Yutaka Suzuki Nobutsugu Abe Toshiyuki Mori Yutaka Atomi |
| |
Institution: | (1) Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan |
| |
Abstract: | Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations
of mucin-producing epithelial cells with excessive mucus production and cystic dilatation of the pancreatic ducts. IPMNs have
malignant potential and exhibit a broad histologic spectrum, ranging from adenoma to invasive carcinoma. IPMNs are classified
into main duct and branch duct types, based on the site of tumor involvement. IPMN patients have a favorable prognosis if
appropriately treated. The postoperative 5-year survival rate is nearly 100% for benign tumors and noninvasive carcinoma,
and approximately 60% for invasive carcinoma. A main duct type IPMN should be resected. Surgical treatment is indicated for
a branch duct IPMN with suspected malignancy (tumor diameter ≥ 30 mm, mural nodules, dilated main pancreatic duct, or positive
cytology) or positive symptoms. Malignant IPMNs necessitate lymph node dissection (D1). IPMNs are associated with a high incidence
of extrapancreatic malignancies and pancreatic ductal carcinoma. |
| |
Keywords: | intraductal papillary mucinous neoplasm pancreatic cancer |
本文献已被 PubMed SpringerLink 等数据库收录! |
|