基质金属蛋白酶在恶性血液病发病机制中作用的研究进展

基质金属蛋白酶（matrix metalloproteinases，MMPs）在多种血液病中异常表达，它通过降解细胞外基质、影响黏附分子和细胞因子的表达和功能，参与造血干细胞的增殖和分化，影响造血干细胞对骨髓基质细胞的黏附，参与原始及幼稚造血细胞离开骨髓、浸润外周组织的过程，导致肿瘤细胞的免疫逃逸，与疾病的预后密切相关。本文就MMP的结构，MMP的调控机制，MMP与造血干／祖细胞的增殖和分化、血管生成及肿瘤免疫的关系等作一综述。

Progress of Study on the Roles 0f Matrix Metalloproteinases in the Pathogenesis of Hematologic Malignancies-Review

Matrix metalloproteinases （MMPs） have the ability to degrade extracellular matrix components. They abnormally express in a variety of solid tumors and hematologic malignancies, and play an important role in tumor invasion and metastasis through extracellular matrix degradation, which closely relates with the progression and prognosis of the malignant disease. This article reviews progress of study on the mechanism of MMP underlying the pathogenesis of hematologic malignancies, including structure of MMP, regulation mechanism of MMP and its relation with proliferation and differentiation of hematopoietic stem cells （HSC）, angiogenesis and tumor immunology and so on.