| INHIBITORY EFFECT OF DEMO ON THE GROWTH OF TRANSPLANTED HUMAN COLON CANCER IN NUDE MICE |
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| 作者姓名： | 王敏 余海 郑树 陈智周 范振符 林晨 |
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| 作者单位： | Cancer Institute，Zhejiang Medical University，Hangzhou，Cancer Institute，Zhejiang Medical University，Hangzhou，Cancer Institute，Zhejiang Medical University，Hangzhou，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing |
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| 摘 要： | A human colon cancer cell line Hce- 8693 was heterotransplanted in nude mice. Polyamine blosythesis Inhibitor a- dlfiuoromethylomithine (DFMO ) show a marked reproducible inhibition in this model. The size and weight of transplanted tumor In DFMO group were smaller than those of the control group and the average inhibition rate was 72.8% (P < 0.001) . DFMO showed higher tumor inhibitory rate than 5-Fu (35. 4%) (P<0. 001) . Furthermore. DFMO demonstrated less severe bone marrow inhibition in the nude mice than 5-Fu (20. 0% Vs 53. 2%. P<0. 001) .There was no synergistic action in these two drugs at the experimental dose. The concentration of putrescine and spermidine in the plasma and tumor tissue in the DFMO group were 70% lower than those of the control group (P<0. 001) . These results indicate that the anti-tumor effect of DFMO might be explained by the inhibition of polyamine biosynthesis and this study provides an experimental basis for future clinical application of DFMO.
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| 关 键 词： | polyamine α- difluoromethylornithine (DFMO). colon cancer cell line nude mice. |
Inhibitory effect of DEMO on the growth of transplanted human colon cancer in nude mice |
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| Min Wang,Hai Yu,Shu Zheng,Zhizhou Chen,Zhenfu Fan,Chen Lin.INHIBITORY EFFECT OF DEMO ON THE GROWTH OF TRANSPLANTED HUMAN COLON CANCER IN NUDE MICE[J].Chinese Journal of Cancer Research,1991,3(4):18-23. |
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| Authors: | Min Wang Hai Yu Shu Zheng Zhizhou Chen Zhenfu Fan Chen Lin |
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| Institution: | 1. Cancer Institute, Zhejiang Medical University, Hangzhou
2. Cancer Institute, Chinese Academy of Medical Sciences, Beijing
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| Abstract: | A human colon cancer cell line Hce- 8693 was heterotransplanted in nude mice. Polyamine blosythesis Inhibitor a- dlfiuoromethylomithine (DFMO ) show a marked reproducible inhibition in this model. The size and weight of transplanted tumor In DFMO group were smaller than those of the control group and the average inhibition rate was 72.8% (P < 0.001) . DFMO showed higher tumor inhibitory rate than 5-Fu (35. 4%) (P<0. 001) . Furthermore. DFMO demonstrated less severe bone marrow inhibition in the nude mice than 5-Fu (20. 0% Vs 53. 2%. P<0. 001) .There was no synergistic action in these two drugs at the experimental dose. The concentration of putrescine and spermidine in the plasma and tumor tissue in the DFMO group were 70% lower than those of the control group (P<0. 001) . These results indicate that the anti-tumor effect of DFMO might be explained by the inhibition of polyamine biosynthesis and this study provides an experimental basis for future clinical application of DFMO. |
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| Keywords: | polyamine α - difluoromethylornithine (DFMO) colon cancer cell line nude mice |
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