| 莫西沙星与加替沙星治疗慢性阻塞性肺疾病急性加重期疗效比较 |
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| 引用本文： | 李炜,李立民. 莫西沙星与加替沙星治疗慢性阻塞性肺疾病急性加重期疗效比较[J]. 中国药房, 2007, 18(32): 2526-2527 |
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| 作者姓名： | 李炜 李立民 |
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| 作者单位： | 华北煤炭医学院附属唐山市中医院,唐山市,063000 |
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| 摘 要： | 目的:比较莫西沙星与加替沙星治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及安全性。方法:63例AE-COPD患者随机分成治疗组(30例)与对照组(33例),分别给予莫西沙星和加替沙星治疗7~14d。结果:治疗结束后第7天,治疗组与对照组的临床有效率分别为90.00%、81.82%(P>0.05),细菌清除率分别为79.17%、72.73%(P>0.05),不良反应发生率分别为13.33%、18.18%(P>0.05)。结论:莫西沙星同加替沙星一样,对AECOPD临床疗效确切、安全,可作为AECOPD的经验性抗感染药。
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| 关 键 词： | 莫西沙星 加替沙星 慢性阻塞性肺疾病急性加重期 |
| 文章编号： | 1001-0408（2007）32-2526-02 |
| 收稿时间： | 2006-12-19 |
| 修稿时间： | 2007-03-20 |
Moxifloxacin vs.Gatifloxacin for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
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| LI Wei,LI Limin. Moxifloxacin vs.Gatifloxacin for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. China Pharmacy, 2007, 18(32): 2526-2527 |
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| Authors: | LI Wei LI Limin |
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| Affiliation: | Tangshan Municipal Hospital of TCM Affiliated to North China Coal Medical College, Tangshan 063000, China |
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| Abstract: | OBJECTIVE:To evaluate the efficacy and safety of moxifloxacin vs.gatifloxacin in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).METHODS:A total of 63 AECOPD patients were enrolled:30(trial group) were randomly treated with moxifloxacin and other 33(control group) with gatifloxacin all for 7～14days.RESU-LTS:On the seventh day after the completion of treatment period,in the trial group vs. control group,the total clinical effective rate was 90.00% vs.81.82%(P>0.05),the bacterial eradication rate was 79.17% vs. 72.73% (P>0.05),and the incidence of adverse drug reaction was 13.33% vs.18.18%(P>0.05).CONCLUSION:Moxifloxacin and gatifloxacin were alike for both have confirmed efficacy and safety for AECOPD and can be used as empirical anti-infective medicine. |
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| Keywords: | Moxifloxacin Gatifloxacin Acute exacerbation of chronic obstructive pulmonary disease |
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