| Hepatoprotective effects of diethylcarbamazine in acute liver damage induced by carbon tetrachloride in rats |
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| 作者姓名： | Ricardo GONZALEZ Odelsa ANCHETA Marlien MARQUEZ Sandra RODRIGUEZ |
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| 作者单位： | Department of Pharmacology，National Center for Scientific Research，Apartado 6990，Ciudad Habana，Cuba |
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| 摘 要： | This research was carried out to determine a potential role of leukotrienes in the acute hepatotoxicity induced by CC14 in rats. An inhibitor of leukotrienes biosynthesis, diethylcarbamazine (DEC, 25 and 50 mg ·kg-1 ip) exerted hepatoprotective effects, decreasing the activity of alanine aminotransfer-ase in serum and the concentration of liver triglycerides. DEC reduced histological damage of liver evidenced by electron microscopy. The hepatoprotective effects of DEC were dose-dependent. The results favor the role of leukotrienes in CC14 hepatotoxicity.
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Hepatoprotective effects of diethylcarbamazine in acute liver damage induced by carbon tetrachloride in rats |
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| Ricardo GONZALEZ,Odelsa ANCHETA,Marlien MARQUEZ,Sandra RODRIGUEZ.Hepatoprotective effects of diethylcarbamazine in acute liver damage induced by carbon tetrachloride in rats[J].Acta Pharmacologica Sinica,1994(6). |
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| Authors: | Ricardo GONZALEZ Odelsa ANCHETA Marlien MARQUEZ Sandra RODRIGUEZ |
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| Abstract: | |
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| Keywords: | diethylcarbamazine liver carbon tetrachloride poisoning alanine amino- transferase triglycerides |
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