纳米银涂层尿管抗菌作用的临床对比研究

目的:研究纳米银涂层尿管的抗菌作用. 方法:神经外科留置导尿患者30例,随机分为纳米银抗菌尿管组、普通尿管组,留置尿管时间小于7 d者剔除,达到入组要求患者30例,其中纳米银抗菌尿管组17例、普通尿管组13例,导尿前、导尿后7,14,21,28 d留取中段尿查白细胞、细菌培养,拔除尿管后,尿管末端行细菌培养. 结果:导尿前、导尿后7,14,21,28 d普通尿管组尿白细胞阳性数分别为1,5,6,8,9;纳米银抗菌尿管组分别为0,1,2,4,5;普通尿管组尿培养阳性数分别为0,3,5,7,8,纳米银抗菌尿管组分别为0,0,1,3,4,后者明显降低(P《0.05). 尿培养普通尿管组大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌、草绿色链球菌、变形杆菌分别为3,4,3,1,2例次;纳米银抗菌尿管组为2,1,1,1,0例次. 尿管培养普通尿管组大肠埃希菌、铜绿假单胞菌、金黄色葡萄球菌、草绿色链球菌、变形杆菌分别为8,3,4,3,2例次;纳米银抗菌尿管组为3,1,2,0,1,后者低于前者(P《0.05). 结论:纳米银涂层尿管具有一定抗菌作用.

Clinical contrast study of antibacterial action by urinary catheters coated with nanometer-silver

AIM: To study the antibacterial action of urinary catheters coated with nanometer-silver.METHODS: Cathe-terized patients in neurosurgery department were randomly divided into 2 groups:ordinary urinary catheter group and urinary catheter coated with nanometer-silver group.After the patients with catheterization time less than 7 d were rejected,all 30 patients were studied including 17 with urinary catheter coated with nanometer-silver and 13 with ordinary urinary catheter.Urine routine and urine culture were done before and 7,14,21,28 d after urethral catheterization.The end of urinary catheters was cultured after a urinary catheter was pulled out.RESULTS: The positive number of urinary leukocytes before and 7,14,21,28 d after urethral catheterization was 1,5,6,8,9,respectively for ordinary urinary catheter group,but for urinary catheter coated with nano-meter-silver group it was 0,1,2,4,5,respectively(P<(0.05)).The positive number of urine culture before and 7,14,21,28 d after urethral catheterization was 0,3,5,7,8,respectively for ordinary urinary catheter group,but for urinary catheter coated with nanometer-silver group it was 0,0,1,3,4,respectively(P<0.05).The Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureaus,Streptococcus viridans and Proteus species were found in 3,4,3,1,2 cases respectively in urine culture for ordinaryurinary catheter group,but for urinary catheter coated with nanometer-silver group those were found in 2,1,1,1,0 cases respectively.Those microorganisms were found in 8,3,4,3,2 cases respectively in urinary catheter culture for ordinary urinary catheter group,but for urinary catheter coated with nanometer-silver group,they were found in 3,1,2,0,1 cases respectively (P<(0.05)).CONCLUSION: Catheters coated with nanometer-silver have an antibacterial action.