| 丹参/三七不同配比药效学比较研究——对急性实验性心肌缺血犬心肌生化标志物的影响 |
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| 引用本文： | 商洪才,张伯礼,高秀梅,王怡,康立源,李玉红,杜嵘,江海涛. 丹参/三七不同配比药效学比较研究——对急性实验性心肌缺血犬心肌生化标志物的影响[J]. 天津中医药, 2002, 19(2): 43-45 |
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| 作者姓名： | 商洪才 张伯礼 高秀梅 王怡 康立源 李玉红 杜嵘 江海涛 |
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| 作者单位： | 1. 天津中医学院,300193
2. 天津中医学院中医药研究中心,300193 |
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| 基金项目： | 国家重点基础研究发展规划资助项目(G1999054403) |
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| 摘 要： | 目的观察丹参/三七的7种配比对心肌生化标志物的影响.方法采用经典模型——冠脉前降支结扎法,经十二指肠给药,测量实验起止点的心肌钙蛋白(cTnI)和肌酸激酶同工酶(CK-MB).结果两种生化标志物反映的结果并不一致,7种配比中10/0、10/1、10/3、10/6、10/10均能使cTnI降低(P<0.05,P<0.01);10/0、10/1、10/3、10/6、1/10、0/10可使CK-MB降低(P<0.05).结论丹参对心血管的直接作用要优于三七.
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| 关 键 词： | 丹参 三七 药效学 心肌钙蛋白 肌酸激酶同工酶 |
| 文章编号： | 1004-5392(2002)02-0043-03 |
| 收稿时间： | 2001-09-24 |
| 修稿时间： | 2001-09-24 |
Comparative Research on Pharmacodynamics of Different Matching of Danshen and Sanqi-Effect on Myocardial Biochemical Indices of Dog with Experimental Acute Myocardial Ischemia(AMI) |
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| Shang Hongcai,Zhang Boli,Gao Xiumei. Comparative Research on Pharmacodynamics of Different Matching of Danshen and Sanqi-Effect on Myocardial Biochemical Indices of Dog with Experimental Acute Myocardial Ischemia(AMI)[J]. Tianjin Journal of Traditional Chin Medicine, 2002, 19(2): 43-45 |
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| Authors: | Shang Hongcai Zhang Boli Gao Xiumei |
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| Affiliation: | Tianjin University of Traditional Chinese Medicine, Tianjin 300193;Tianjin University of Traditional Chinese Medicine, Tianjin 300193;Tianjin University of Traditional Chinese Medicine, Tianjin 300193;Tianjin University of Traditional Chinese Medicine, Tianjin 300193;Tianjin University of Traditional Chinese Medicine, Tianjin 300193;Tianjin University of Traditional Chinese Medicine, Tianjin 300193 |
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| Abstract: | Objective: To observe the effect of 7 different proportions of Danshen Root and Sanqi on myocardial biochemical indiced in dogs with AMI.Methods: AMI model was produced in dog by coronary artery ligation. CTnI and CK-MB concentrations were measured after duodenal administration of drugs. Results: cTnI could be reduced at the proportion of 10/0,10/1,10/3, 10/6,10/10(P<0.05,P<0.01), while CK-MB lowered at the proportion of 10/0,10/1,10/3,10/6.1/10,0/10(P<0.05). Conclusion: The direct effect of Danshen Root on cardiovascular function was better than Sanqi. |
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| Keywords: | Danshen Root Sanqi Pharmacodynamics cTnI CK-MB |
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