神经源性、梗阻性和特发性逼尿肌不稳定模型的建立和尿动力学测定

目的：比较不同原因所致逼尿肌不稳定（detrusor instability,DI）在尿动力学测定结果方面有无异同。方法：建立大鼠膀胱流出道梗阻（bladder outlet obstruction,BOO）、脊髓损伤（spinal cord injury,SCI）以及特发性逼尿肌不稳定（idiopathic detrusor instability,IDI）的模型,6周后再行充盈性膀胱测压,观察膀胱容量、顺应性变化及DI的发生情况。结果：成功建立不同DI模型,DI-BOO发生率为75.9%,DI-SCI发生率100%,IDI发生率为21.3%。与正常对照组相比,各模型组膀胱最大容量和顺应性变化有显著性差异（P〈0.05）。结论：不同原因所致的逼尿肌不稳定的尿流动力学表现不尽一致,但却均有逼尿肌不稳定收缩波存在,其发病机理有无共性有待进一步探讨。

Urodynamic study of detrusor instability caused by neurogenic, obstructive and idiopathic factors in rats

Objective:To compare the urodynamic change of the rat model with detrusor instability caused by obstructive,neurogenic and idiopathic factors.Methods: Eighty female SD rats were enrolled in this study,including 17 rats with idiopathic detrusor instability(IDI),33 with bladder outlet obstruction(BOO) by partial ligation of bladder outflow tract,20 with spinal cord injury(SCI) by transection of spinal cord at L1-2,and 10 as normal control.Six weeks later,followed by a filling cystometry,the capacity,pressure change,bladder compliance and the probability of DI were observed.Results: The occurrence rates of detrusor instability in BOO,SCI and IDI rats were 75.9 %,100%,and 21.3% respectively.The maximum cystometric capacity and the bladder compliance were obviously difference among four groups(P<0.05).Conclusion: Detrusor instability induced by different causes may have different urodynamic results,but similar instable contraction exists in them.It is essential to investigate whether they have common etiopathogenesis of detrusor instability.