一氧化氮在急性出血坏死性胰腺炎肠道损伤中保护作用的研究

目的：探讨一氧化氮（ＮＯ）在急性出血坏死性胰腺炎（ＡＨＮＰ）时肠损伤的作用。方法：用去氧胆酸钠逆行注射法复制ＡＨＮＰ模型。将ＳＤ大鼠随机分为三组：假手术组（ＳＯＧ）；急性出血坏死性胰腺炎组（ＡＰＧ）；Ｌ－ＮＡＭＥ治疗组（ＬＴＧ）。分别测定术后１、４、８、１２ｈ各组血清淀粉酶和肠组织ＮＯ含量，对胰腺和小肠组织作病理检查，并进行病理组织评分。结果：ＳＯＧ术后血清淀粉酶无明显变化，ＡＰＧ和ＬＴＧ血清淀粉

Actions of nitric oxide in intestinal tract damaging following acute hemorrhagic necrotizing pancreatitis

Objective:To study the relationship between nitric oxide(NO)and intestin damages when acute hemorrhagic necrotizing pancreatitis(AHNP)occurs,and might provide some help to research and treat intestine damage of AHNP.Methods:Copying AHNP model with retrograde injection of deoxysodium cholate into pancreatic duct,SD rats were randomly divided into three groups:sham operation group(SOG);acute hemorrhagic necrotizing pancreatitis group(APG);L-NAME treatment group(LTG).Then serums amylaes and NO content of intestine tissue at the lst,4th,8th and 12th hour were measured.The pancreas and intestine tissues were examined pathologically.Results:There was no remarkable changes of serums amylase level in SOG.The serums amylase levels were higher in APG and LTG at every phase.NO content of intestine tissue was higher of APG than LTG at every phase.The pathological and histological changes of pancreas and intestine tissues of LTG was only a little different from APG at lst and 4th,but worse than APG at the 8th.Conclusions:NO has the protective function in intestinal damage process at the occurrence of AHNP and also has the occurrence function in pancreas at occurrence of AHNP.