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| 基质金属蛋白酶-2在膀胱癌和阴茎癌组织中的表达及其意义 | |
| 引用本文： | 李向东,薄爱华,邢立强,张晓丽,白丽娜. 基质金属蛋白酶-2在膀胱癌和阴茎癌组织中的表达及其意义[J]. 实用癌症杂志, 2003, 18(6): 595-596,603 |
| 作者姓名： | 李向东 薄爱华 邢立强 张晓丽 白丽娜 |
| 作者单位： | 1. 075029,张家口医学院第一附属医院泌尿科 2. 075029,张家口医学院实验中心 3. 075000,张家口沈家屯医院 |
| 摘 要： | 目的 探讨基质金属蛋白酶 (MMP 2 )在膀胱癌和阴茎癌组织中的表达及其意义。方法 采用免疫组化方法 ,检测42例膀胱癌和 45例阴茎癌组织中MMP 2的表达水平。结果 MMP 2在阴茎癌组织中的阳性表达率为 5 7.78% ( 2 6/4 5 ) ,高分化者阳性表达率为 45 .16% ( 14 /3 1) ,中低分化者阳性表达率为 85 .71% ( 12 /14 ) ,2组有显著性差异 (P <0 .0 5 )。MMP 2在膀胱癌组织中阳性表达率为 2 8.5 7% ( 12 /4 2 ) ,在移行细胞癌和腺癌组织中阳性表达率分别为 2 3 .68% ( 9/3 8)和 75 .0 0 % ( 3 /4 ) ,两者比较有非常显著性差异 (P <0 .0 1)。结论 MMP 2水平可作为阴茎癌和膀胱癌术后综合治疗及预后判断的生物学指标 |
| 关 键 词： | 基质金属蛋白酶-2 膀胱癌 阴茎癌 表达 癌组织 |
| 文章编号： | 1001-5930(2003)06-0595-02 |
Expression of Maxtrit Melalloproteinase-2 and its Significance in Bladder Carcinoma and Penis Carcinoma |
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| LI Xiang-dong,BO Ai-hua,XING Li-qiang et al. Expression of Maxtrit Melalloproteinase-2 and its Significance in Bladder Carcinoma and Penis Carcinoma[J]. The Practical Journal of Cancer, 2003, 18(6): 595-596,603 | |
| Authors: | LI Xiang-dong BO Ai-hua XING Li-qiang et al |
| Affiliation: | LI Xiang-dong,BO Ai-hua,XING Li-qiang et al. Department of urological,First Attiliated Hospital,Zhang Jiakou Medical College,Zhang Jiakou,075000 |
| Abstract: | Objective To study the expression of matrix metalloproteinase-2 and its significance in bladder carcinoma and penis carcinoma.Methods The expression of MMP-2 was detected by SP Immunohistochemical technigue in 42 cases bladder carcinoma and 45 cases penis cancer.Results The expression rate of MMP-2 was 57.78%(26/45) in penis carcinoma.For penis carcinoma,the positive rate of MMP-2 was 45.16%(14/16) in high differentiation group and 85.71%(12/14) in low differentiation group (P<0.05).The positive rate of MMP-2 was 28.57%(12/42) in bladder carcinoma.For bladder carcinoma,the positive rate of MMP-2 was 75.00%(3/4) in adenocarcinoma and 23.68%(9/38) in transitional epithelium carcinoma(P<0.01). Conclusion The expression of MMP-2 can be taken as biological index of comprehensive treatment and prognosis in penis cancer and bladder cancer. |
| Keywords: | Matrix metalloproteinase Bladder carcinoma Penis cancer Immunohistochemistry |
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