不同剂量阿司匹林治疗脑梗死的疗效及对血清C反应蛋白的影响

目的探讨不同剂量阿司匹林治疗脑梗死的临床疗效及对于血清C反应蛋白(CRP)的影响。方法收集我院收治的脑梗死患者60例为脑梗死组,随机分为A组、B组和C组各20例。分别应用50mg/d、100mg/d及300mg/d阿司匹林治疗,选择同期健康体检者20例作对照组(D组),比较A、B、D组的临床疗效,并与D组比较CRP水平。结果脑梗死组血清CRP水平显著高于D组(P0.05),治疗后A、B、C组CRP均显著降低,且C组显著低于A、B组(P0.05);治疗后A、B、C组NIHSS评分均显著降低(P0.05),且C组显著低于A、B组(P0.05);C组总有效率为90.0%,显著高于A组的60.0%和B组的75.0%(P0.05);3组不良反应无明显差异(P0.05)。结论阿司匹林治疗脑梗死可显著改善患者的神经功能并降低血清CRP水平,疗效显著,且其疗效存在剂量依赖性,大剂量疗效显著且安全可靠,值得推广应用。

The effects of aspirin at different doses in the treatment of cerebral infarction and on serum C-reactive protein

Objective To investigate the effects of aspirin at different doses in the treatment of cerebral infarction and on serum C‐reactive protein .Methods Sixty cases of cerebral infarction in our hospital from January 2012 to December 2014 were selected randomly divided into group A ,group B and group C ,20 cases in each group ,which received 50 mg/d ,100 mg/d and 300 mg/d of aspirin ,respectively .Simultaneously ,20 healthy people were selected as group D .Then clinical efficacy and CRP levels of group A ,B ,C were compared .Results The serum CRP levels of each cerebral infarction group were significantly higher than that of group D (P<0 .05) .After treatment ,the CRP levels and NIHSS scores of group A ,B ,C were significantly de‐creased ,and group C showed significantly lower level and scores than group A and group B (P<0 .05) .Additionally ,after treatment ,the total effective rate in group C was 90 .0% ,significantly higher than 60 .0% in group A and 75 .0% in group B (P<0 .05);There were no significant differences between each group in terms of adverse events (P>0 .05) .Conclusion Aspirin can significantly improve the neural function and decrease the serum CRP level in a dose‐dependent manner ,with remarkable clinical ef‐ficacy in cerebral infarction patients .We draw a conclusion that high‐dose aspirin can be safe and should be widely applied .