原发性癫痫合并阻塞性睡眠呼吸暂停低通气综合征的临床特点 |
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引用本文: | 项正兵,屈新辉,谢旭芳,吴晓牧. 原发性癫痫合并阻塞性睡眠呼吸暂停低通气综合征的临床特点[J]. 中国实用神经疾病杂志, 2016, 0(6): 4-5. DOI: 10.3969/j.issn.1673-5110.2016.06.003 |
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作者姓名: | 项正兵 屈新辉 谢旭芳 吴晓牧 |
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作者单位: | 江西省人民医院神经内科 江西省神经病学研究所 南昌 330006 |
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基金项目: | 国家临床重点专科建设项目(卫办医政函[2012]649号) |
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摘 要: | 目的探讨原发性癫痫合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的临床特点。方法回顾性分析2007-06-2014-06在我院确诊的16例原发性癫痫合并OSAHS患者的临床资料(包括病史、多导睡眠脑电图及治疗随访)。结果癫痫形式表现为全面强直阵挛发作13例,部分性发作3例,其中夜间发作11例,白天发作5例;多导睡眠脑电图(polysomnography,PSG)显示均为阻塞性睡眠呼吸暂停低通气综合征(OSAHS),其中重度9例,中度4例,轻度3例。所有患者经抗癫痫药物治疗及OSAHS的指导性治疗。其中4例癫痫伴重度OSAHS经单纯药物治疗仍反复发作,联合丙戊酸钠和经鼻持续气道正压通气(CPAP)治疗,随访0.5~3a,发作频率减少3例,发作停止1例。结论原发性癫痫合并OSAHS一般以中老年男性多见,癫痫类型以夜间全面强直阵挛性发作为主,对于单纯抗癫痫药物治疗不佳者,药物联合CPAP治疗可取得明显效果。
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关 键 词: | 原发性癫痫 阻塞性睡眠呼吸暂停低通气综合征 临床特点 |
Clinical features of obstructive sleep apnea hypopnea syndrome in patients with idiopathic epilepsy |
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Abstract: | Objective To investigate the clinical characteristics of obstructive sleep apnea hypopnea syndrome(OSAHS) in patients with epilepsy.Methods Clinical data(mainly including history,polysomnography,therapy and follow-up visits) of 16 idiopathic epilepsy cases with OSAHS admitted to our hospital from June 2007 to June 2014 were analyzed retrospectively.Results Of all the 16 cases,generalized tonic-clonic seizures occurred in 13 cases and partial seizures in 3 cases,11 cases happened at night and 5 cases happened in the daytime.Of all patients diagnosed as OSAHS by the monitor of polysomnography,there were 4 severe OSAHS,4 moderate OSAHS and 3 mild OSAHS.Patients with severe OSAHS still repeated seizures after the treatment of simple antiepileptic drugs,but the frequency of seizures decreased in 3 cases and the seizure ceased in 1 case for six months to 3 years follow-up when patients were treated by sodium volproate and continuous positive airway pressure (CPAP).Conclusion OSAHS with epilepsy is much common in middle-aged males.And the main type of seizure is generalized tonic-clonic seizure which usually occurs at night.For patients with worse effect treated by single antiepileptic drug,the combined treatment of antiepileptic drugs and CPAP is more effective. |
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Keywords: | Epilepsy Obstructive sleep apnea hypopnea syndrome Clinical feature |
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