三叉神经痛采用阿霉素神经毁损治疗的临床疗效

目的探讨三叉神经痛采用三种不同浓度阿霉素进行神经毁损治疗的临床疗效。方法回顾性分析我院2013-04—2014-04收治的67例三叉神经痛患者的临床资料,均给予阿霉素神经毁损治疗,按阿霉素使用浓度分为A组(0.33%,22例)和B组(0.50%,22例)、C组(1.00%,23例)。观察3组治疗后2周、6个月、12个月的疼痛评分情况和治疗效果,并进行比较。结果 (1)治疗后2周、6个月、12个月,3组疼痛评分较治疗前均出现显著下降(均P0.05);B组和C组治疗后2周、6个月、12个月的疼痛评分均显著低于A组(均P0.05);治疗后2周、6个月B组和C组之间的疼痛评分比较差异无统计学意义(P0.05),治疗后12个月,B组疼痛评分显著高于C组(P0.05)。(2)治疗后2周、6个月、12个月,B组和C组的治疗优良率均显著高于A组(均P0.05);治疗后2周、6个月B组和C组之间治疗优良率比较差异无统计学意义(P0.05),治疗后12个月,B组治疗优良率显著低于C组(P0.05)。结论利用不同浓度阿霉素对三叉神经痛患者进行神经毁损治疗均可获得一定的效果,其中0.50%和1.00%浓度阿霉素的治疗效果优于0.33%浓度,且1.00%浓度阿霉素的远期疗效优于0.50%浓度。

The clinical effect of nerve block induced by adriamycin in treating trigeminal neuralgia

Objective To explore clinical effects of nerve block induced by adriamycin in three variable concentrations of adriamycin in treating trigeminal neuralgia.Methods A retrospective analysis was performed referring to clinical data of 67 pa-tients with trigeminal neuralgia in our hospital from April 2013 to April 2014.All patients received nerve block by adriamycin, who were divided into group A(0.33%,22 cases),group B(0.50%,22 cases)and group C(1.00%,23 cases)according to the concentration of adriamycin.The pain scores and the effect of the treatment in the three groups were observed two weeks,6 months and 12 months after treatment.Results Pain scores of all groups 2 weeks,6 months and 12 months after treatment were markedly decreased than those before treatment(P <0.05),which were higher in group B and group C compared with group A(P <0.05),and difference was not found between group B and group C 2 weeks as well as 6 months after treatment(P>0.05),but which was found 12 months after treatment(P <0.05).2 weeks,6 months and 12 months after treatment,favora-ble efficiency rate in group B and group C was obviously higher than that in group A(P <0.05),there was no difference be-tween group B and group C 2 weeks and 6 months after treatment(P >0.05),but group B showed higher rate than group C 12 months after treatment(P <0.05).Conclusion The all different concentrations of adriamycin inducing nerve block may work well in patients with trigeminal neuralgia,and concentrations of 0.50% and 1.00% take advantages over 0.33%,the long-term curative effect of 1.00% concentration may be better than that of 0.50% concentration.