小剂量地塞米松在脑梗死急性期的治疗作用研究

目的探讨小剂量地塞米松在脑梗死急性期的治疗作用。方法 120例脑梗死患者随机分为地塞米松治疗组、安慰剂组及对照组,对照组只给予常规治疗,地塞米松治疗组为常规治疗+1mL(5mg)地塞米松注射液,安慰剂组则为常规治疗+1mL注射用水,各组分别于治疗后1个月及3个月行血常规及红细胞沉降率检查,同时采用Barthel指数及改良Rankin量表对受试对象进行神经功能评定。结果地塞米松治疗组红细胞沉降率较安慰剂组及对照组明显减慢,差异有统计学意义(P0.05)。根据Barthel指数及改良Rankin量表评定结果,地塞米松治疗组神经功能明显改善,较安慰剂组及对照组明显增加,差异有统计学意义(P0.05)。结论小剂量地塞米松在脑梗死急性期发挥了神经保护作用。

Clinical study of effect of low-dose dexamethasone for acute cerebral infarct

Objective To study effect of low-dose dexamethasone for acute cerebral infarct. Methods One hundred and twenty patients with acute cerebral infarct were randomly divided into dexamethasone treatment group ,placebo group and con-trol group. Subjects in control group ,dexamethasone treatment group and placebo group received conventional therapy ,con-ventional therapy + 1 mL(5 mg) dexamethasone injection and conventional therapy + 1 mL water for injection ,respectively. Af-ter treatment of 1 month and 3 months ,complete blood count and erythrocyte sedimentation rate were tested ,and neurological function was evaluated by Barthel index and modified Rankin Scale (mRS). Results The erythrocyte sedimentation rate in dexamethasone treatment group was significantly different from that of placebo group and control group (P< 0.05). Moreo-ver ,there were significantly differences between dexamethasone treatment group and placebo group as well as control group in neurological function by Barthel index and mRS (P < 0.05). Conclusion Low-dose dexamethasone plays a neuroprotection role on acute cerebral infarct .