低分子肝素联合丹参注射液治疗急性脑梗死的效果分析

目的探讨低分子肝素和丹参注射液联合治疗急性脑梗死的临床效果。方法选取2012-12—2015-01我院诊治的急性脑梗死患者95例,随机分为研究组(n=48例)和对照组(n=47例),对照组实施基础治疗与丹参注射液,观察组加用低分子肝素治疗。比较2组治疗前后血液流变情况、神经功能改变情况(NIHSS评分),并评定临床疗效、并发症情况。结果2组治疗后血液流变学指标(纤维蛋白原、红细胞比积、血浆黏度、全血低切黏度、全血高切黏度)均明显低于治疗前(P0.05),且研究组较对照组降低更明显(P0.05);治疗后7、14、28d2组NIHSS评分均较治疗前明显降低(P0.05),且研究组各时点NIHSS评分较对照组更低(P0.05);研究组与对照组总有效率分别为91.67%和74.47%,研究组高于对照组(P0.05);2组并发症发生情况无明显差异(P0.05)。结论低分子肝素联合丹参注射液治疗急性脑梗死,患者脑部循环明显改善,效果显著,值得推广。

Analysis of the efficacy of low molecular weight heparin combined with Danshen injection in the treatment of acute cerebral infarction

Objective To evaluate the clinical efficacy of low molecular weight heparin combined with Danshen injection in the treatment of acute cerebral infarction. Methods Totally 95 cases of acute cerebral infarction patients in our hospital from December 2012 to January 2015 were chosen ,and were randomly divided into the study group (48 cases) and the control group (47 cases). The control group received the basic treatment combined with Danshen injection ,while the study group trea-ted by the basic treatment combined Danshen injection and low molecular weight heparin. The change of blood rheology ,nerv-ous function (NIHSS score) before and after treatment in two groups were compared ,and clinical efficacy ,complication were e-valuated. Results After treatment ,the indexes of hemorheology (fibrinogen ,hematocrit ,plasma viscosity ,whole blood low shear viscosity ,whole blood high shear viscosity ) in two groups were significantly lower than that before treatment ( P <0.05) ,and the study group decreased more obviously than control group (P< 0.05) ;after the treatment of 7 ,14 ,28d ,the NIH-SS scores in two groups were lower than those before treatment(P< 0.05) ,and the NIHSS scores in the study group at each time were significantly lower than those of control group (P< 0.05) ;the total effective rate of the study group and the control group were 91.67% and 74.47% ,the study group was higher than control group (P< 0.05) ;the complication in two groups had no significant difference (P > 0.05). Conclusion Low molecular weight heparin combined with Danshen injection in treatment of acute cerebral infarction patients ,cerebral blood circulation is improved obviously ,the effect is significant ,which is worthy of promotion .