| 氧化应激对大鼠心肌梗死后心室重构的影响 |
| |
| 引用本文： | 周淑娴,周艳,雷娟,张玉玲.氧化应激对大鼠心肌梗死后心室重构的影响[J].南方医科大学学报,2008,28(11):2030-2034. |
| |
| 作者姓名： | 周淑娴 周艳 雷娟 张玉玲 |
| |
| 作者单位： | 中山大学附属第二医院心内科,广东,广州,510120 |
| |
| 摘 要： | 目的 探讨大鼠急性心肌梗死后氧化应激对心室重构的影响.方法 制备雄性SD大鼠急性心肌梗死模型(n=20)和假手术对照(n=12),于手术后6周观察心脏及心脏重量指数(HMI)、左室重量指数(LVMI)、右室重量指数(RVMl)、心功能指标、非梗死区心肌细胞凋亡指数、梗死区及非梗死区心肌胶原含量、Ⅰ型及Ⅲ型胶原比值以及心肌组织的氧化代谢指标.结果 心肌梗死后HMI、LVMI、RVMI增加,心功能下降(P<0.05,P<0.01);心肌细胞凋亡指数、非梗死区心肌胶原含量均增加,心肌组织Ⅰ型、Ⅲ型胶原比值升高(P<0.05,P<0.01);心肌组织超氧化物歧化降低.丙二醛含量升高,二者的比值降低(P<0.05);相关性分析提示心肌组织氧化应激水平与心功能指标、心肌细胞凋亡指数、胶原含量、胶原Ⅰ/Ⅲ比值均存在相关.结论 氧化应激参与心室重构的病理生理过程,干预氧化应激可作为防治心室重构的手段.
|
| 关 键 词： | 心肌梗死 心室重构 胶原 细胞凋亡 氧化应激 |
Effects of oxidative stress on ventricular remodeling after myocardial infarction in rats |
| |
| ZHOU Shu-xian,ZHOU Yan,LEI Juan,ZHANG Yu-ling.Effects of oxidative stress on ventricular remodeling after myocardial infarction in rats[J].Journal of Southern Medical University,2008,28(11):2030-2034. |
| |
| Authors: | ZHOU Shu-xian ZHOU Yan LEI Juan ZHANG Yu-ling |
| |
| Institution: | ZHOU Shu-xian,ZHOU Yan,LEI Juan,ZHANG Yu-ling Department of Cardiology,Second Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,China |
| |
| Abstract: | Objective To investigate the effects of oxidative stress on ventricular remodeling after acute myocardial infarction (AMI) in rats.Methods AMI was induced in 20 SD rats by ligation of the anterior descending coronary artery,and another 12 rats without the ligation served as the sham-operated group.Six weeks after the operation,the heart mass index (HMI),left ventricular mass index (LVMI),right ventricular mass index (RVMI),the indexes of heart function,cardiac myocyte apoptosis index,collagen content and co... |
| |
| Keywords: | myocardial infarction ventricular remodeling collagen cell apoptosis oxidative stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
