血清总胆汁酸在新生儿黄疸诊断中的临床意义

目的通过检测血清总胆汁酸(TBA)水平,确定总胆汁酸在新生儿黄疸诊断治疗中的临床应用价值。方法采用循环酶速率法,检测生理性黄疸、病理性黄疸患儿TBA水平,同时对其肝功能相关指标进行测定。结果生理性黄疸组的DBIL、ALT、TBA低于病理性黄疸组(P<0.05),尤其是生理性黄疸组的DBIL和TBA值明显低于病理性黄疸组(P<0.01)。生理性黄疸的ALT异常率及TBA异常率明显低于病理性黄疸组(P<0.01)。结论血清TBA测定能较好地诊断病理性黄疸患儿,是反映不同程度的胆汁淤积、肝实质性损伤的重要指征,可为临床提供诊断和治疗依据。

Clinical Significance of Serum Total Bile Acid in the Diagnosis of Neonatal Jaundice

Objective To discuss the clinical application value of total bile acid in the diagnosis and treatment of neonatal jaundice through the detection of total bile acid(TBA)level.Methods Enzymatic cycling method was used to test serum total bile acids in physiologic jaundice and pathological jaundice and detect the index of liver function.The results were compared.Results The DBIL,ALT,TBA of physiological jaundice group were lower than pathological jaundice group(P<0.05),especially the DBIL and TBA value(P<0.01).The abnormal ALT rate and abnormal TBA rate of physiological jaundice group were significantly lower than the pathological jaundice group(P<0.01).Conclusion Serum TBA test can be used to diagnose pathological jaundice babies well,which can reflect the important index of different degrees of cholestasis and substantive liver damage,thus can provide reference for clinical diagnosis and treatment.