2型糖尿病患者和一级亲属血浆胆囊收缩素的变化及意义

目的观察2型糖尿病患者(T2DM)及其一级亲属(FDRs)血浆胆囊收缩素(CCK)水平的变化并分析其相关因素。方法2003-062003-10将河北省人民医院的观察对象分为正常对照组(21例)、FDRs组(35例)、T2DM组(32例),检测受试者体重、空腹胰岛素、空腹血糖及血浆CCK水平变化,对比各组之间生化指标变化。以体重指数(BMI)=25kg/m~2为界限重新分组后进一步分析CCK与BMI的关系。结果血糖、BMI在对照组、FDRs组、T2DM组有逐渐升高趋势,但只在T2DM与对照组间差异有统计学意义(P<0·05)。CCK、胰岛素在对照组、FDRs组、T2DM组逐渐增高,且差异显著(均P<0·01)。以BMI为据分组后,FDRs组、T2DM组BMI>25kg/m~2的受试者胰岛素、CCK水平均明显高于同组BMI<25kg/m~2,血糖差异无显著性。结论T2DM及FDRs血浆CCK水平明显增高,其变化与胰岛素水平变化相似。肥胖可能与CCK、胰岛素水平变化有关。

The changes of the plasma cholecystokinin level in type 2 diabetic patients and their first-degree relatives

Objective To investigate the changes of the plasma cholecystokinin(CCK)level in type 2 diabetic patients(T2DM)and their first-degree relatives(FDRs)and analyze related factors.Methods Three groups were studied,health control group,FDRs group and T2DM group.The body weight,fasting blood sugar,fasting insulin and CCK of those subjects were measured.The change of CCK was compared between each group,and the relationship with BMI was analyzed.Results Age and sex of each group were matching.There was a step-up trend of glucose and BMI in control,FDRs and T2DM groups,but there was statistical difference only between T2DM and control(P<0.05).CCK and insulin in control,FDRs and T2DM groups increased gradually(all P<0.01).Based on BMI=25 kg/m~2,CCK and insulin of the subjects BMI>25 kg/m~2 of FDRs and T2DM groups were significantly higher than those of the subjects BMI<25 kg/m~2 of the same group.Conclusion The plasma cholecystokinin levels increase significantly in T2DM and FDRs,and the change was similar to the change of insulin.Obesity may be related to the changes of CCK and insulin.