| GM-CSF在辐射后的变化及其在辐射损伤治疗中的应用 |
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| 引用本文： | 王治东. GM-CSF在辐射后的变化及其在辐射损伤治疗中的应用[J]. 国际放射医学核医学杂志, 2003, 27(1): 38-41 |
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| 作者姓名： | 王治东 |
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| 作者单位： | 100850 北京, 军事医学科学院放射医学研究所 |
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| 摘 要： | GM-CSF是较早发现的一种造血生长因子,在某些刺激条件下可由多种细胞合成分泌,能够刺激骨髓造血祖细胞增殖和分化,刺激中性、嗜酸性粒细胞及巨噬细胞增殖和成熟,也可以促进巨核细胞生长,对红细胞生长有辅助调节作用。GM-CSF水平在辐射后动物体内发生明显的变化,对辐射损伤后造血的恢复具有很好的治疗效果。
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| 关 键 词： | GM-CSF 辐射 造血 |
| 文章编号： | 1001-098X(2003)01-0038-04 |
| 收稿时间： | 2002-09-27 |
| 修稿时间： | 2002-09-27 |
Expression of GM-CSF level after radiation and application in the radiation injury |
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| WANG Zhi-dong. Expression of GM-CSF level after radiation and application in the radiation injury[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2003, 27(1): 38-41 |
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| Authors: | WANG Zhi-dong |
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| Affiliation: | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China |
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| Abstract: | GM-CSF is the early discovered hematopoietic growth factor.Various kind of cells can synthesize and secreted GM-CSF by some stimulation.GM-CSF can stimulate the proliferation and differentiation of bone marrow hematopoietic progenitor cells and activate the proliferation and maturity of neutrophils,eosinophils,and macrophages.GM-CSF also stimulate growth of megakaryocyte and erythrocyte.Some change of GM-CSF level can be found after radiation in animal,which can accelerate the recovery of radiation injury. |
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| Keywords: | GM-CSF irradiation hematopoiesis |
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