氟比洛芬酯复合舒芬太尼用于食管癌切除术后镇痛的临床观察

目的观察氟比洛芬酯复合舒芬太尼用于食管癌切除术患者术后静脉自控镇痛（PCIA）的效果。方法择期行食管癌根治术患者45例术后均行静脉自控镇痛，随机分为3组（n=15）：对照组（C组），PCIA泵中含芬太尼20μg／kg、托烷司琼5mg；F1组，PCIA泵中含芬太尼10μg／kg、氟比洛芬酯100mg、托烷司琼5mg；F2组：PCIA泵中含舒芬太尼0．2μg／kg、氟比洛芬酯100mg、托烷司琼5mg。观察患者术后镇痛、镇静及不良反应情况。结果在术后各时间点，C组和F1组镇痛视觉模拟评分无统计学意义（P〉0．05）；在术后12h、24h、48h，F2组镇痛视觉模拟评分低于C组和F1组（P〈0．05），3组镇静效果和不良反应无统计学意义（P〉0．05）。结论氟比洛芬酯复合舒芬太尼具有较强镇痛作用，且不增加不良反应，可作为临床术后镇痛模式选择。

Clinical Observation of Patient Controlled Intravenous Analgesia with Flurbiprofen Axetil and Sufentanil on Patient of Esophagus Carcinoma Resection

Objective To observe patient controlled intravenous analgesia（PCIA） effects of flurbiprofen axetil and sufentanyl on patient of esophagus carcinoma resection. Methods Forty-five patients were randomly divided into three groups with 15 cases each. group C （postoperative： fentanyl 20μg/kg ＋ tropisetron 5 mg） ,group F1 （postoperative： fentanyl 10 μg/kg ＋ flurbiprofen axetil 100mg ＋ tropisetron 5 mg）,group F2 （postoperative： sufentanyl 0.2 μg/kg ＋ flurbiprofen axetil 100mg ＋ tropisetron 5 mg）. The VAS score, sedation score and side effect were recorded at 1, 12, 24, 48 hours after operation. Results Patients did not show any significant difference in the VAS scores in group C and group F1 atlh, 12h, 24h, 48h after operation（P 〉 0.05）. The VAS scores of patients in group F2 was significantly lower than that in group C and group F1 at12h, 24h, 48h after operation（P 〈0.05）. The sedation scores and side effects were no significant difference in three groups（P 〉 0.05）. Conclusion Flurbiprofen axetil and sufentanyl in patient controlled intravenous analgesia have evident analgesia effect and don＇t increase side effect.