不同免疫程序接种钩端螺旋体菌苗的血清学效果观察

本文报道了1977~1980年桃源县部分钩体病疫区菌苗免疫效果的观察结果。
分别设四个组，以不同的免疫方法接种钩体菌苗。连年免疫组（每年加强一针）；间隔一年免疫组；间隔二年免疫组和间隔三年免疫组。
经过基础免疫后一年，抗体水平较高，滴度为1：34.89~179.6。再免疫后抗体可大幅度上升，最高可达1：129~1646。另外自然隐性感染亦可得到较强的免疫力。
根据检测结果我们认为在钩体病流行区，如果已查明宿主动物和流行株，易感人群必需进行相应群的钩体菌苗作基础免疫后，再继续加强免疫两年，抗体在机体中可保持较高水平甚至终身。但必须密切监测钩体流行株的变迁。

An Observation on Serological Response to Leptospiral Vaccine Injected through Different Routes

This result was obtained in epidemic area of leptospirosis in Tao Yuan county in 1977-1980.
The investigation was done by using different immunization processes with leptospiral vaccine in four brigades, namely, the group of vaccination every year; the group of vaccination at an interval of one year; the group of vaccination at an interval of two years and the group of vaccination at an interval of three years.
One year after basic vaccination the level of the antibody was rather high with a titer of 1::34.89-179.6 After vaccination the titer were increased markedly, being 1:129-1646. Besides, relatively strong immunity might also be obtained from natural inapparent infection. We are of the opinion that if the strains of leptospira responsible for the epidemics and animal reservoir hosts were identified in the epidemic region of leptospirosis, the susceptible human population must receive a basic vaccination with corresponding group of leptospiral vaccine, followed by booster vaccination for two years then the antibody may maintain at a rather high level even lifelong. But Close surveillance of the changing of leptospiral strains responsible for the epidemic should be done.