Phase II study of combination bleomycin,vincristine and high-dose methotrexate (BOM) with leucovorin rescue in advanced squamous cell carcinoma of the anal canal |
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| Authors: | Nils Wilking Nicholas Petrelli Lemuel Herrera Arnold Mittelman |
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| Institution: | (1) Department of Surgical Oncology, Roswell Park Memorial Institute, 666 Elm Street, 14263 Buffalo, NY, USA |
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| Abstract: | Summary Fifteen patients with advanced squamous cell carcinoma of the anal canal were treated with a combination of bleomycin, vincristine, and high-dose methotrexate (BOM) with leucovorin rescue. Three out of twelve patients with measurable disease had objective responses of 1, 2, and 5 months. Five of the fifteen patients had severe or life-threatening complications as a result of this treatment regimen. The narrow therapeutic index of the BOM therapy makes it a less than ideal drug combination for the treatment of advanced squamous cell carcinoma of the anal canal.Aided by Grant JFCF 793, American Cancer Society, New York, New York |
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