249例尖锐湿疣及湿疣样病变形态学及HPV原位杂交对照观察

收集２４９例临床诊断或怀疑为尖锐湿疣的活检标本作病理形态学观察，组织学诊断为尖锐湿疣１４８例，可疑１８例，炎性增生８３例。抽取其中３０例尖锐湿疣、１０例可疑尖锐湿疣、１５例炎性增生作地高辛标记的ＨＰＶ６Ｂ／１１ＤＮＡ原位杂交。结果：尖锐湿疣组均阳性，可疑组１例阳性，炎性增生组均阴性。本文对尖锐湿疣的病理诊断及鉴别诊断进行了讨论。本组材料中的９２．８％的病例在组织学上得到了确诊，并且和ＨＰＶ６Ｂ／１１原位杂交结果相符，仅７．２％病例组织学列为可疑，需进一步作ＨＰＶ检测。

Pathological and in situ hybridization study of 249 cases of condyloma acuminatum and condylomatoid lesion

biopsies which were diagnosed as condyloma clinically were studied histologically, 148 cases were diagnosed as condytoma acuminatum, 18 cases as suspicious condyloma, 83 cases as inflammatory hyperplasia. We took 30 cases of condyloma acuminatum, 10 cases of suspicious condyloma and 25 cases of inflammatory hyperplasia from the 249 cases to detect hurnan papillomavirus DNA by in situ nucleic acid hybridization using digoxin labelled HPV 6B/11 probes. Results showed that the 30 cases of condyloma acuminatum were all positive, 1 case of suspicious condyloma was positive, and all cases of inflammatory hyperplasia were negative. We discussed the pathological diagnosis and differential diagnosis of condyloma. 92. 8% of our cases were diagnosed histopathologically, and accorded with the result of HPV 6B/11 in situ hybridization. Only 7. 2% of the cases which were diagnosed as suspicious condyloma need to be detected with HPV further.